Elliot Winters and Dr. Steven M. Johnson, MM Biology Main Text The purpose of this project has its roots in the nationwide mission named “ENCODE” for the “ENCyclopedia Of DNA Elements” the purpose of which is to map the functional elements of the human genome. The human genome was successfully sequenced in 2001, (Consortium T.I.H.G.S., […]
Function of Novel Nuclear-Variant Bone Morphogenic Protein (nBMP2) In Muscle Fiber Type Differentiation
Nicholas Wallace and Dr. Laura Bridgewater, Microbiology & Molecular Biology Bone morphogenetic proteins (BMPs) are in the transforming growth factor B (TGF-) super family of proteins, which were originally identified by their ability to induce bone formation in animals.A novel nuclear variant of BMP2 (nBMP2) was recently discovered by Dr. Bridgewater and her graduate researchers. […]
Identification of Yersiniapseudotuberculosisgenes that affect Congo-red binding
Ryan Stewart and Dr. David Erickson Abstract The plague bacterium Yersiniapestisrecently evolved from the enteric pathogen Yersiniapseudotuberculosis, during which time it has adopted a flea-borne lifestyle. Y. pestisforms a biofilmin the flea digestive tract to enhance transmission, whereas Y. pseudotuberculosisdoes not. Biofilmformation requires the hmsgenes, which direct the production of an N-acetylglucosamineextracellular matrix (ECM) that […]
PAS Kinase Interactions
Steven Sowa and Dr. Julianne Grose, Microbiology Goal To discover the substrates of PAS kinase. Introduction Signal transduction pathways are critical to the function of a cell. Correct signals help the cell to manage its resources effectively while improper or inactive signals contribute to cancer and many other human diseases. One protein involved in signal […]
A Multiplex Real-time PCR Assay for Rapid Detection and Differentiation of Burkholderia mallei, B. pseudomallei, and B. thailandensis
Chinn-Woan Shih and Richard Robison, Department of Microbiology and Molecular Biology Main Text As stated in the proposal, my focus has been with three bacterial species of Burkholderia: mallei, pseudomallei, and thailandensis. Burkholderia mallei is the causative agent of glanders, an abscess-forming infection that is predominantly found in the equine population and is capable of […]
Quantification of Kaposi’s Sarcoma Herpesvirus Gene Expression in Infected Humanized Mice
Mark Rowan and Dr. Bradford K. Berges, Microbiology & Molecular Biology Kaposi’s Sarcoma Herpesvirus (KSHV) is a prevalent disease around the world. Some Sub- Saharan African countries have infection levels as high as 40 percent. Usually the effects of this disease are not fatal unless the infected person has already been infected with HIV or […]
Real-time, in Vivo, NAD Biosensor
Jonathan Neubert and Dr. Julianne Grose, Microbiology and Molecular Biology Main Text Nicotinamide adenine dinucleotide (NAD) is a crucial coenzyme used in the production of ATP and general cellular metabolism. Its structure consists of two nucleotides—pyridine and adenine—joined by a pyrophosphate bond. The pyridine allows the molecule to function as an electron carrier in the […]
The Effect of Kalanchoe-Pinnata Extract on Epstein-Barr Virus
Miles Murri and Dr. Brian D. Poole, Microbiology and Molecular Biology Main Text For the last year I have been working on a project that would test the efficacy of a potential drug on a common human virus called Epstein-Barr Virus (EBV). Though the virus often resides in a latent or dormant state, it is […]
Function of Novel Nuclear Bone Morphogenetic Protein 2 in regulating Inositol 1,4,5-triphosphate Receptor 1 Expression
Broc McCune and Dr. Laura Bridgewater, Microbiology and Molecular Biology Main Text Bone morphogenetic protein 2 (Bmp2) is a well-characterized secreted transforming growth factor. Researchers in the lab of Dr. Laura Bridgewater, Brigham Young University, discovered a novel nuclear variant of Bmp2 (nBmp2)1. Preliminary data indicates that mice not expressing nBmp2 have difficulty regulating intracellular […]
The Contribution of CCR9 to the Homing, Migration, and Accumulation of IgA Antibody Secreting Cells in Mouse Salivary Glands
Susanne Linderman with Dr. Eric Wilson, Microbiology and Molecular Biology IgA is the most common antibody isotype involved in the immune system’s defense of mucosal membranes. In order to migrate and accumulate at these sites, IgA antibody secreting cells rely on chemokines. These chemokines, which are proteins differentially secreted in different tissues, bind to chemokine […]
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