Caitlin Munger and Dr. John Kauwe, Biology Introduction Late-onset Alzheimer’s disease (LOAD) is a fatal neurodegenerative disease and is the sixth leading cause of death in the US. There are currently no successful therapies to prevent or treat LOAD, and predicting disease status remains a challenge1. Apolipoprotein E (APOE)—a gene involved in cholesterol regulation—is the […]
Robust and Versatile Bioinformatic Pipeline Development
Ryan Hillary and Dr. Seth Bybee, Department of Biology Introduction: With the many advances in sequencing technology and exponential growth of computational capacities there comes a huge demand for processing larger and larger quantities of data. With respect to Biology there can be hundreds of gigabytes of data that can be involved in a single […]
Assessment of TREM2 rs75932628 Association with Alzheimer’s Disease in a Population-based Sample: The Cache County Study
Josue D. Gonzalez Murcia a,1, Cameron Schmutz a,1, Caitlin Munger a, Ammon Perkes a, Aaron Gustin a, Michael Peterson a, Mark T.W. Ebbert a,b, Maria C. Norton c,d, JoAnn T. Tschanz d, Ronald G. Munger e, Christopher D. Corcoran f, John S.K. Kauwe a Abstract Recent studies have identified the rs75932628 (R47H) variant in TREM2 […]
Genetic Variants in the APOE Gene Region Responsible for Change in Cerebrospinal Fluid AB42 Protein Levels
Spencer Foutz and Dr. John Kauwe, Department of Biology Introduction For the last several years, the e4 allele in the APOE gene region has been a strong determinant of the development of Amyloid Beta plaques in the brain’s cerebral spinal fluid. As these plaques aggregate, the deposits become increasingly deadly to neuronal cells, and can […]
Biodiversity and Distribution of Entomophilic Nematodes in Utah’s Mojave Region
Westen Archibald and Dr. Byron Adams, Biology To better understand the diversity and distribution of entomophilic nematodes in Utah’s Mojave region, I have begun a project that’s purpose is to develop phylogenetic maps of 55 nematode species that I have already extracted from the soils of the Beaver Dam wash ecotone. This project involves both […]
A Multi-Faceted Approach to Improving ADAMTS13 Deficiency Prediction Algorithm
Steven Nevers, David Brandt, and Matthew Biggs 1 Abstract Despite previous work by our group and other researchers, the existing methods to predict ADAMTS13 deficiency are inadequate. Through the use of machine learning techniques applied to mined patient data we have improved the accuracy and efficiency of our existing ADAMTS13 deficiency prediction algorithm. In conjunction […]
Single Nucleotide Polymorphism Discovery in Cutthroat Trout Subspecies using Genome Reduction, Barcoding, and 454 Pyro-sequencing
Derek D Houston, David B Elzinga, Peter J Maughan, Scott M Smith, John SK Kauwe, R Paul Evans, Ryan B Stinger, Dennis K Shiozawa Abstract Background Salmonids are popular sport fishes, and as such have been subjected to widespread stocking throughout western North America. Historically, stocking was done with little regard for genetic variation among […]
Choose Your Daddy: Genetic Genealogy to Prevent Dairy Cow Production-Related Diseases
Nalani Yamada and Professor Beverly Roeder DVM, PhD, Biology Department Dairy cows are bred and utilized to produce large quantities of milk daily and are held to high production standards. Greater production or manipulated production activity can affect the homeostasis state of an animal and lead to production-related metabolic diseases (PRMDs). In a previous study focused […]
Determining the Presence of Micro RNA in the Untranslated Regions of AdipoQ, a Metabolism Gene
Victoria Scott and Dr. John (Keoni) Kauwe, Biology Department Goal/Purpose: The purpose of this project is to sequence the untranslated region of the AdipoQ gene and interrogate it for novel genetic variation and potential microRNA sequences. This work will illuminate how adiponectin levels are regulated and provide insights into type II diabetes, metabolic syndrome, and […]
Validation of Genetic Association between Variants in PPP3R1 and MAPT and Rate of Progression of Alzheimer’s Disease
David Peterson and Dr. John S. K. Kauwe, Biology Introduction Alzheimer’s disease (AD) is the most common neurodegenerative disease, affecting more than 4.5 million people in the US. Genetic studies of AD have previously identified mutations in three genes (APP, PSEN1 and PSEN2) and polymorphism in APOE as risk factors. These findings have led to […]
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