Eric Nelson, Chemistry and Biochemistry I was awarded the Research and Creative Work Scholarship for the winter semester of 1994 based on my proposal to synthesize a novel organic compound for testing and publication in conjunction with the research group of Dr. Jerald Bradshaw in the Chemistry Department. The Compound as described in my proposal […]
Phosducins: Evidence For The Evolution of New Proteins Through Gene Duplication
Tim Rand and Dr. Barry Willardson, Chemistry & Biochemistry Introduction The theory of evolution by natural selection is arguably the most important scientific theory ever formulated. Its importance has not been manifest in an “ooh, ah” technological way—it doesn’t empower us to fly airplanes or to illuminate streets at night—but no scientist really thinks technology […]
A Novel Human Angiotensin Ii Type 1 Receptor Isoform Elicits an Exaggerated Angiotensin Ii-induced Response
Terry S. Elton and Dr. James W. Ogilvie Jr., Biochemistry and Chemistry Hypertension (i.e., high blood pressure) is a significant health problem affecting more than 15% of the population contributing to the increased incidence of heart failure, kidney failure and stroke. The renin-angiotensin system (RAS) plays a pivotal role in salt and water homeostasis and […]
Report of Progression on The Synthesis of a Conformational Amphiphile for Nondestructive Diffusion Through Membrane Bilayers
Paul B. Savage and Dr. David B. McMullin, Chemistry and Biochemistry The stability of all cellular life in the presence of adverse environmental conditions may be attributed to the function of cellular membranes. Membranes are unique in their ability to act as barriers with selective permeability (1). Such selective permeability allows cells to control and […]
AN INVESTIGATION OF THE INFLUENCE OF POLAR VS. POLARIZABLE SUBSTITUENTS IN POLYSILOXANE STATIONARY PHASES FOR GAS CHROMATOGRAPHY
Sarah Morgan, Chemistry For my creative work and research scholarship project I proposed the synthesis of four polymers for use as stationary phases in gas chromatography. Each polymer would contain a pendant group with a halogen-substituted benzene ring, making use of the four halogen atoms-fluorine, chlorine, bromine, and iodine. Since these atoms lie along a […]
UPDATE ON THE RECONSTRUCTION OF THE CYTOCHROME B GENE OF THE EXTINCT M4MMUTHUS COLUMBI
Natalie Mincek, Chemistry The intent of this project was to reconstruct the cytochrome B gene from the extinct mammoth Mammuthus columbi. This was to be accomplished through amplification by PCR the fragments of the cytochrome B gene in order to determine their respective sequences, after which these DNA sequences would be combined to reconstruct the […]
THE SEPARATION OF TRANSITION METALS USING MACROCYCLES ADSORBED ON A REVERSED PHASE CoLUMN
Anthony P. Giauque, Chemistry and Biochemistry Standard protocol for the analysis of transition metals by conventional chromatographic means calls for the complexation of the transition metal cations prior to their separation. Consequently, this addition of a complexing agent does not allow for conductimetric detection of transition metals due to the high conductivity of the complexing […]
THE HYDROLYTIC INTERACTION OF PHOSPHOLIPASE A2 AND LYSOLECITHIN
Brian Baker, Chemistry and Biochemistry The purpose of my project was to determine whether the hydrolysis of lysophosphatidylcholine occurs at the sn-1 or the sn-2 position. I found that the rate of acyl migration is about 17 times slower than the hydrolytic rate. Additionally, the hydrolytic rate varies with the source of the enzyme. Both […]
Expression, Activity and Inhibition of Canine Cyclooxygenase
Joel Ellis Wilson and Dr. Dan Simmons, Chemistry and Biochemistry Nonsteroidal anti-inflammatory drugs (NSAIDs) exhibit their effect by inhibiting the cyclooxygenase (COX) enzymes. However, inhibition of both COX-1 and COX-2 by the administration of NSAIDs to both humans and animals often leads to negative side effects, most commonly gastric toxicity, including ulcers, which may progress […]
Multivariate Analysis of Elemental Concentrations in Various Lichen Growth Forms
Seth Washburn and Dr. Nolan Mangelson, Chemistry Lichens consist of two organisms that live in a symbiotic relationship. The lichen photobiont, green alga, cyanobacteria, or a combination of both, provides carbohydrates from photosynthesis. While the mycobiont partner, a fungus, accounts for the majority of the lichen mass, and provides shelter and nutrients (St. Clair, 1998). […]
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