Matthew J. Hinton and Dr. Roger G. Harrison, Chemistry and Biochemistry An exciting area of research is based on the idea that small molecules can be used to perform the same chemical reactions as enzymes. In living organisms, enzymes play important roles in facilitating the vast majority of biochemical reactions necessary for life. One particular […]
SYNTHESIS OF LIPID A ANALOGS FOR USE IN STUDYING THE BINDING OF LIPID A AND POLYMYXIN B
Bryce A. Harrison and Dr. Paul B. Savage, Chemistry and Biochemistry Lipid A (1 in Fig. 1) is a bacterial compound that can cause sepsis, an overreaction of the immune system during bacterial infections.1 Because no good treatment is known, sepsis causes over 100,000 deaths annually in the U.S.1 Treatments for sepsis are difficult to […]
Removal of Abundant Non-Informative Proteins from Blood Serum for Biomarker Discovery
Nathan Lewis and Dr. Craig D. Thulin, Department of Chemisty and Biochemistry Biomarkers play a key role in disease diagnosis and in guiding physicians in treatment selection. Blood serum is potentially the best tissue for biomarker discovery and detection for several reasons. First, blood is already routinely drawn for tests. Second, serum preparation is highly […]
Biomimetic and Amino-Retinoid Compounds: Potential Applications in Cancer and Age-Related Macular Degeneration
Kam Lau and Dr. Heidi Vollmer-Snarr, Chemsitry and Biochemistry Department Introduction Cancer is the second leading cause of death in the United States. According to the American Cancer Society, about half of all men and one-third of all women in the US will develop cancer during their lifetimes. Today, millions of people are living with […]
Antibiotic Thin Films
Timothy Jennings, Jason Nielsen, Brian Ratcliff, Nina Wallace, Xin Zhong Lai, Paul B. Savage, Department of Chemistry and Biochemistry Abstract Nosocomial infections lead to septicemia, a severe problem in the United States. The Savage group has developed a novel class of antibiotics (CSAs) that can be attached to polymers. Invasive medical equipment can be coated […]
Genetic Analysis of Protein Folding
Daniel Chan and Dr. Allen Buskirk, Chemistry and Biochemistry Proteins are of the utmost physiological importance in their roles as enzymes, structural elements, and antibodies. Correctly formed proteins catalyze biochemical reactions, initiate proper immune system response, and even promote the development of hair, bones, skin, muscles, and blood. Likewise, incorrectly formed proteins cause Alzheimer’s disease, […]
Three-Dimensional Modeling of Two Forms of the Hepatitis B Virus
Rebecca Baum and Dr. David M. Belnap, Chemistry and Biochemistry The hepatitis B virus (HBV) is a pathogen that causes liver disease and death in over one million individuals per year. It is an enveloped retrovirus that is composed of a protein capsid surrounding a nucleic acid core. This nucleic acid core, depending upon the […]
NONSTEROIDAL ANTI-INFLAMMATORY DRUG INDUCED APOPTOSIS VIA A NOVEL COX-I/COX-2 INDEPENDENT PATHWAY
Gregory C. Chipman and Dr. Daniel L. Simmons, Chemistry and Biochemistry My efforts were concentrated in assisting Phillip M. Robertson, a graduate student in the Department of Chemistry and Biochemistry, in researching the cellular action of a family of drugs, nonsteroidal anti-inflammatory drugs. Nonsteroidal anti-inflammatory drugs (NSAIDS) include aspirin, ibuprofen, diclofenac, and other pharmacologically important […]
STRUCTURAL IDENTIFICATION OF THE BIOACTIVE COMPONENTS OF THE SAMOAN FISH POISON PLANT BARRINGTONIA ASIATICA
Robert A Burton and Dr. Noel L. Owen, Chemistry and Biochemistry The seed of the Futu tree, Barringtonia asiatica, has been used by inhabitants of the Pacific islands for many years as a highly toxic fish poison.1 These ethnobotanical studies were responsible for the initiation of this investigation. Successful completion of this project required a […]
DETERMINATION OF ANGIOTENSIN II TYPE 2 RECEPTOR PROTEIN INTERACTIONS USING THE YEAST-TWO HYBRID SYSTEM
Emily Janeen Westover and Dr. Terry S. Elton, Chemistry and Biochemistry The renin-angiotensin system plays a central role in water and salt homeostasis, electrolyte balance, and vascular tone maintenance. 1 Each component of this system is a potential effector in the etiology of hypertension. Angiotensin II (Ang II), a component of the reninangiotensin system, interacts […]
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