Dr. John Bell, Department of Physiology & Developmental Biology Abstract of original proposal Secretory phospholipase A2 (sPLA2) binds to and hydrolyzes cell membranes. It is important in inflammatory responses and diseases including septic shock, atherosclerosis, and cancer. Normally, cells resist the enzyme’s action, but they become susceptible early during the process of either biochemically-programmed or […]
Search Results for: novel
Co-amplification of Mitochondrial Pseudogenes
Dr. Michael Whiting, Department of Biology Funding was received from the BYU ORCA mentorship program during 2011 to support undergraduates performing research in my lab, under the mentorship of postdoctoral researchers, graduate students, and myself. During 2011, this funding provided direct support for 6 undergraduates who are in various stages of completing research projects. The […]
Development of Real-Time Polymerase Chain Reaction (q-PCR) Assays for the Specific Detection and Characterization of Select Bacterial Pathogens
Dr. Richard Robison, Department of Microbiology & Molecular Biology The Specific aims for the project were as follows Develop q-PCR reactions for specific target genes of bacterial pathogens Primer generation software will be used to design primer and probe sequences that will theoretically perform optimally in PCR reactions. All sequences will be subjected to BLAST […]
Cytokine Signaling in the Microenvironment May Aid in Tumor Development and Progression
Dr. Kim O’Neill, Department of Microbiology and Molecular Biology Studies have indicated that in breast tumors a high number of tumor associated macrophages (TAM’s) is indicative of a poor prognosis. TAM’s in the breast tumor microenvironment generally have a compromised immune response and focus their energy toward tissue repair which leads to angiogenesis, tumor growth, […]
Endocannabinoid Enzyme Expression in the Hippocampus
Dr. Jeff Edwards, Department of Physiology & Developmental Biology Evaluation of academic objectives of the proposal The objectives of this award were met, especially in regard to the mentoring focus of the award. The students have been mentored and trained in an effective manner as outlined below. Using this mentoring environment and the experiences gained […]
Down Syndrome Pathway Analysis
Dr. Mark Clement, Department of Computer Science Many of the most serious medical problems that plague humanity are caused by problems in the genetic regulatory network. Heart disease, cancer and many other maladies could be cured if we understood how genes interact with each other in order to produce different symptoms. Many of these problems […]
Receptors for Advanced Glycation End-Products (RAGE) Mediates Particulate Matter-Induced Pulmonary Inflammation
Dr. Paul Reynolds, Department of Physiology & Developmental Biology Academic Objectives Met and Results Observed Funding available through this MEG award has provided an opportunity for me to meet many academic objectives I’ve determined to be important in the early stages of my faculty appointment at BYU. First of all, I have been able to […]
The Function of Yeast PAS kinase
Dr. Julianne Grose, Department of Microbiology & Molecular Biology Evaluation of academic objectives PAS kinase is a newly discovered member of the nutrient sensing kinases that regulates glucose homeostasis in mice and yeast. The aim of our 2009 MEG “The Function of Yeast PAS kinase” was to characterize the role of a known PAS kinase […]
The Role of Nuclear Bmp2 (nBmp2) in Skeletal Muscle
Dr. Laura Bridgewater, Department of Microbiology & Molecular Biology The goal of this project was to characterize the molecular pathway by which nBmp2 disrupts Ca2+ handling in skeletal muscle of nBmp2 mutant mice. Previously, we had worked with Dr. Chad Hancock’s lab to measure muscle function in nBmp2 mutant mice, and those results showed a […]
Finding Plagiarizing and Undesirable Web Documents by Utilizing Word Similarity in the Fuzzy Set Information Retrieval Model
Dr. Yiu-Kai Dennis Ng, Department of Computer Science Evaluation of the Academic Objects In the 2007 MEG proposal, I specified the following Internet problems to be solved using a Fuzzy set information retrieval (IR) model: (i) detecting plagiarism, which is the act of using another’s words or ideas as one’s own, (ii) filtering junk emails, […]