Mary Rennick and Dr. Brent Nielsen, Department of Microbiology and Molecular Biology Beginnings This research focused on the search for the probable mitochondrial DNA (mtDNA) mutation in one family affected with fibromyalgia and lactic acidosis. The hypothesis was that there is mixture of normal and mutated mtDNA, called heteroplasmy. I first obtained the four patients’ […]
Search Results for: molecular
Antibody Production and Diversification in Humanized Mice
Stanton Nielsen and Dr. Brad Berges, Department of Microbiology and Molecular Biology Many scientists are skeptical of using humanized mice to study the human adaptive immune response. The reasoning behind this skepticism stems from discrepancies in various studies seen previously. A study conducted by Traggiai et al. showed that humanized mice elicited a human adaptive immune response when […]
How ‘bout them Apples?: A Study on Antioxidants
Kylie Measom and Dr. Kim O’Neill, Department of Microbiology and Molecular Biology They say “an apple a day keeps the doctor away.” Apples are laden with antioxidants which have been shown to prevent against cancer and other illnesses.1 Antioxidants are molecules that prevent cancer by collecting excess free radicals in the body. Free radicals are […]
Characterizing Proteins that Interact with PAS Kinase
Jordan Mackay and Dr. Julianne Grose, Department of Microbiology and Molecular Biology Characterizing the interacting protein partners of Per-Arnt-Sim (PAS) kinase has proven to be a formidable task. Since the beginning of 2012, I have been working hard with graduate student Desi DeMille on confirming the putative interactors uncovered by genetic screening done the previous […]
The Spondyloepiphyseal Dysplasia Congenita homozygous Mutant: A Model for the Mechanism of Osteoarthritis
David Macdonald and Dr. Robert Seegmiller, Department of Physiology and Developmental Biology Articular cartilage is a hard-wearing and specialized form of hyaline cartilage which allows for an almost frictionless surface during joint movement (Ofek et al. 2008). These unique characteristics are primarily due to chondrocyte secretions, and the composition and properties of the extracellular matrix (ECM) (Buckwalter and […]
EBI2 Knockdown and Effects on B-Cell Migration
Jordan Mabey and Dr. Brian Poole, Department of Microbiology and Molecular Biology Introduction B cells are specialized cells which participate in the normal immune response to an infection. As B cells encounter antigens in the body, they become activated and travel to what is known as a B cell follicle within a lymph node. At […]
Phylogeny of Acridoidea (Orthoptera: Caelifera) based on Complete Mitochondrial Genome Data: Testing Partition Strategies
James Leavitt and Dr. Michael Whiting, Department of Biology Goal/Purpose of the Project The orthopteran superfamily Acridoidea (Orthoptera, Caelifera), which includes grasshoppers and their nearest relatives, is the largest of the orthopteran superfamilies and provides an excellent model for studying the evolution of mitochondrial genomes. Ultimately I was able to reconstruct a phylogeny for Caelifera […]
Assessing the Effects of the IRF5 Exon 1B on Translation
Jared Lambert and Dr. Brian Poole, Department of Microbiology and Molecular Biology With our lab’s previous finding revealing a hairpin folding structure in exon 1B (IRF5 risk allele), not found in the other first exons, this project was focused towards more fully understanding the role of IRF5 exon 1B’s hairpin structure and its effect on […]
Accumulation of Attached Chemokines on Gram-negative Bacterial Membranes
Peter Janzen and Dr. Eric Wilson, Department of Microbiology and Molecular Biology The purpose of this project was to see if a genetic alteration to gram-negative bacteria would affect the phenotypic ability to resist the attachment of chemokines. In other words, we were trying to see if we could change the structure of a bacterium […]
Student Resistance to the Inquiry Method of Instruction in the Biological Sciences
Liahona Hamblin and Dr. Jamie Jensen, Department of Biology The purpose of this study was to test student resistance to the inquiry method of instruction in tertiary introductory biology classes. Proven to be beneficial, the “inquiry” method differs from confirmatory “cookbook” laboratory experiences in that students explore phenomena and solve problems (Prince & Felder, 2007). […]
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