Kimberly Dalton and Dr. Allan Judd, Physiology and Developmental Biology The amount of cortisol within the human body must remain at just the right level to adequately mediate the physiological stress response. With elevated cortisol levels, the immune system is suppressed, and the organism becomes vulnerable to infection. With reduced cortisol levels, the immune system […]
Search Results for: expression
Dimorphic Expression Of Medial Basal Hypothalamic-Preoptic Area Calbindin-D28k mRNA During Perinatal Development In Sprague-Dawley Rats
Emily Brinton Stuart and Dr. Edwin D. Lephart, Neuroscience Introduction Calbindin-D28K (CALB), a calcium binding protein, is one of the most abundant proteins found in neurons of certain brain areas. It is potentially important in neuron formation and may play a protective role against programmed cell death [1]. CALB helps regulate the amount of calcium […]
Independent Murine Biosynthesis of Threonine: Expression of a Complete Bacterial Biosynthetic Pathway in Mice
Ryan D. McAllister and Dr. David Kooyman, Animal Science Threonine is one of the 20 common amino acids found in nature. It is a limiting factor for the growth of many non-ruminant animals such as swine and mice and must be obtained from their diet. When threonine is absent from the diet of these animals, […]
Determining the Expression Patterns of Developmental Genes in Tribolium
Cecily P. Vaughn and Dr. Randy Bennett, Zoology Development in animals is controlled by a set of genes called homeotic genes whose protein products regulate the expression of other genes. Although many homeotic genes have been locates in numerous organisms, there is still much that remains to be learned about the manner in which these […]
Expression, Activity and Inhibition of Canine Cyclooxygenase
Joel Ellis Wilson and Dr. Dan Simmons, Chemistry and Biochemistry Nonsteroidal anti-inflammatory drugs (NSAIDs) exhibit their effect by inhibiting the cyclooxygenase (COX) enzymes. However, inhibition of both COX-1 and COX-2 by the administration of NSAIDs to both humans and animals often leads to negative side effects, most commonly gastric toxicity, including ulcers, which may progress […]
Effects of siRNA-mediated silencing of Phosducin-like Protein Expression on Protein Folding by the Cytoplasmic Chaperonin Complex
Sarah Warburton and Dr. Barry Willardson, Chemistry and Biochemistry Our lab has recently described an interaction of Phosducin-like protein (PhLP) with the cytoplasmic chaperonin complex (CCT), a sixteen polypeptide complex required for the native folding of actin and tubulin and many other cellular proteins. We found that the binding of PhLP blocked CCT-dependent folding of […]
Bax Over-expression Coupled With Bcl-2 Suppression Under The Control of The Cancer-specific Thymidine Kinase Promoter
Brian H. Ladle and Dr. Kim L. O’Neill, Microbiology As researchers continue to discover the molecular origins of cancer, gene therapy targeting cellular processes gone awry shows great promise as the future in cancer treatment. Extensive research is being done to develop more effective techniques targeting different cellular events. One pathway receiving increased attention is […]
Establishing a Mammalian Expression System for Cyclooxygenase-2
Nathan K Evanson and Dr. Daniel L Simmons, Chemistry and Biochemistry Cyclooxygenases are proteins that make small molecules called prostaglandins, which relay signals from one cell to another, or from one cell to itself. Prostaglandins are involved in many different physiological processes such as inflammation, contraction of smooth muscle, and regulation of water balance in […]
Apostle and Scientist John A. Widtsoe’s Views of Evolution: Development, Influences, and Expression
Amy Elisabeth Johnson and Dr. Alan Parrish, Religion John A. Widtsoe, a member of the Church of Jesus Christ of Latter-day Saints who later became an apostle, was also one of the most renowned and respected scientists of his day. During the turn of the century and the early twentieth century, his work in scientific […]
Selenium Alters NF- B-Regulated Gene Expression in Human Prostate Cancer Cells
Aimee L Taylor and Dr. Merrill J Christensen, Nutrition, Dietetics and Food Science Introduction The American Cancer Society estimates that prostate cancer will account for 30% of new cancers in men, totaling over 189,000 new cases, with 30,200 deaths in 2002 (1). Because of its high prevalence and long latency time prostate cancer is an […]
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