Dr. Laura Bridgewater, Department of Microbiology & Molecular Biology The goal of this project was to follow up on preliminary data suggesting that nBmp2 directly activated transcription. A few months of follow-up experiments, however, showed that the original transcription data was not reproducible. At that point we turned our attention to two different questions about […]
Search Results for: cells
Secretory phospholipase A2
Dr. John Bell, Department of Physiology & Developmental Biology Abstract of original proposal Secretory phospholipase A2 (sPLA2) binds to and hydrolyzes cell membranes. It is important in inflammatory responses and diseases including septic shock, atherosclerosis, and cancer. Normally, cells resist the enzyme’s action, but they become susceptible early during the process of either biochemically-programmed or […]
Development of Real-Time Polymerase Chain Reaction (q-PCR) Assays for the Specific Detection and Characterization of Select Bacterial Pathogens
Dr. Richard Robison, Department of Microbiology & Molecular Biology The Specific aims for the project were as follows Develop q-PCR reactions for specific target genes of bacterial pathogens Primer generation software will be used to design primer and probe sequences that will theoretically perform optimally in PCR reactions. All sequences will be subjected to BLAST […]
Cytokine Signaling in the Microenvironment May Aid in Tumor Development and Progression
Dr. Kim O’Neill, Department of Microbiology and Molecular Biology Studies have indicated that in breast tumors a high number of tumor associated macrophages (TAM’s) is indicative of a poor prognosis. TAM’s in the breast tumor microenvironment generally have a compromised immune response and focus their energy toward tissue repair which leads to angiogenesis, tumor growth, […]
Endocannabinoid Enzyme Expression in the Hippocampus
Dr. Jeff Edwards, Department of Physiology & Developmental Biology Evaluation of academic objectives of the proposal The objectives of this award were met, especially in regard to the mentoring focus of the award. The students have been mentored and trained in an effective manner as outlined below. Using this mentoring environment and the experiences gained […]
A Novel Nuclear Variant of nBMP-2: Role in Ca2+ Transport
Dr. Laura Bridgewater, Department of Microbiology & Molecular Biology The goal of this project was to elucidate the role that nBMP-2 plays in Ca2+ transport. In the previous year, we demonstrated that mice that have no nBMP-2 in the nuclei of their cells exhibit delays in the transport of Ca2+ back into the sarcoplasmic reticulum […]
Solar Powered Airplane: Student Design/Build/Fly Project
Dr. Jerry Bowman, Department of Mechanical Engineering Project Objective Involve a significant number of students in a multi-semester project with intense technical challenges and a well-defined objective: The creation of a solar powered airplane with the goal of indefinite flight. Meeting the Academic Objective This mentored education project engaged 61 undergraduate students to contribute to […]
Changes in Membrane Physical Properties during Chemotherapy
Dr. John Bell, Department of Physiology & Developmental Biology Abstract of original proposal Many chemotherapeutic agents treat cancer by inducing programmed cell death (apoptosis) in the tumor. One of the consequences of apoptosis is changes in the physical properties of the cell membrane. Some of these changes are important for other phagocytic cells to recognize […]
Receptors for Advanced Glycation End-Products (RAGE) Mediates Particulate Matter-Induced Pulmonary Inflammation
Dr. Paul Reynolds, Department of Physiology & Developmental Biology Academic Objectives Met and Results Observed Funding available through this MEG award has provided an opportunity for me to meet many academic objectives I’ve determined to be important in the early stages of my faculty appointment at BYU. First of all, I have been able to […]
Interferon Alpha in Systemic Lupus Erythematosus
Dr. Brian Poole, Department of Microbiology & Molecular Biology Evaluation of how well the academic objectives of the proposal were met We presented data from this project at two meetings, 2 presentations at the American society for Microbiology Branch Meeting, Provo UT 2010 and one at the Intermountain Research Symposium, Logan Utah 2010. At the […]