Jared Huber and Dr. Gregory F. Burton GOAL Determine the pathway by which FDC cytokines activate HIV transcription in CD4+ T‐cells harboring latent HIV. BACKGROUND & IMPORTANCE HIV Latency in CD4+ T Cells Human Immunodeficiency Virus (HIV) attacks the immune system by infecting helper (CD4+) T‐cells. HIV injects viral genetic material into the T‐cell, and […]
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Reactivation of latent HIV in CD4+ T cells through FDC costimulation
Matthew Greer and Dr. Greg Burton, Department of Chemistry and Biochemistry I received an ORCA grant for a project entitled “Reactivation of latent HIV in CD4+ T cells through FDC costimulation.” The original hypothesis of this research was that the factor FDCs (follicular dendritic cells) produce to reactivate latent HIV in T cells is a […]
AER Signals Outgrowth of Mesenchyme Cells
Owen Owens and Dr. Jeffery R. Barrow, Physiology and Developmental Biology The Apical Ectodermal Ridge has been of great interest to those studying the development of the mammalian limb every since it was discovered that the AER is vital to the formation of correct limb patterning and general limb formation. The AER is a ridge […]
In vitro Activation of Human Follicular Dentritic Cells and its Effects on Human Immunodeficiency Virus Infection
Sean Llewellyn and Dr. Gregory F. Burton, Department of Chemistry and Biochemistry Importance of Project HIV is known to survive on follicular dendritic cells (FDCs) for many months and is believed to contribute to persisting HIV infection. FDCs protect HIV from degradation, thereby prolonging the infectivity of the virus. Moreover, when virus is trapped on […]
Student Mentoring in Research: Laser-Activated Drug Delivery to Cancer Cells
William G. Pitt, Chemical Engineering Department Summary of Scope of Proposal This proposal was submitted in October of 2011 to organize and fund a mentoring group in the Pitt lab in Chemical Engineering. Marjan Javadi, then a PhD candidate in Chemical Engineering, and 5 uldergraduate students participated in this research group. The purpose was 2-‐fold, […]
The Effects Of Interleukin-1a, Interleukin-6 And Tumor Necrosis Factor- a On The Growth Of Human H295r Cells
Tara Leigh Nelson and Dr. Allan M. Judd, Zoology Cytokines are extracellular signaling proteins or peptides that act as local mediators in cell-cell communication. They regulate several endocrine systems and function in the immune process. These agents mediate cellular proliferation within endocrine tissues, regulate hormone secretion, and control aspects of inflammation (1). Interleukin-1a (IL- 1a), […]
Measles Virus And Its Interactions With Follicular Dendritic Cells
Michael J. Lloyd and Dr. Gregory F. Burton, Microbiology Measles virus continues to be a major cause of death in most third-world countries and a considerable threat to the health of every country. Infection with measles is thought to be associated with the fatal, late-infection disease subacute sclerosing panencephalitis (SSPE) (3). It is thought that […]
Effects of Prematurity on the Presence of Weibel-palade Bodies in Human Umbilical Vein Endothelial Cells in Situ
Niloufar Tabatabeai and Dr. John S. Gardner, Botany & Range Science Newbom, premature infants have greater susceptibility to infection compared to older newborn infants. Although the reason for greater susceptibility to bacterial infection in premature infants is unknown, there are many reports that focus on neutrophils as the defective cell type in the immature neonatal […]
CULTURE AND ISOLATION OF EMBRYONIC STEM CELLS FROM PORCINE BLATOCYSTS
J. Zachary Bruneel and Dr. Jeralyn J. Franson, Animal Science Introduction Embryonic stem (ES) cells are obtained through the culture of undifferentiated cells of embryos in early devel-opment. Because embryonic cells will undergo differentiation and development when placed in standard culture conditions, a media which contains differentiation inhibitors must be used in order for successful […]
Jak/Stat Pathway Utilized by Adrenal Cells in Response to IL-6
Brice Jason Williams and Dr. Allan M. Judd, Zoology In most mammals, the adrenal cortex produces the hormones cortisol, aldosterone, and dehydroepiandrosterone (DHEA). These hormones have profound effects upon water and salt balance, the inflammatory response, and the metabolism of sugars, fats, and proteins. Because of its importance in maintaining homeostasis, the body highly regulates […]
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