Dr. John Bell, Department of Physiology & Developmental Biology Abstract of original proposal Secretory phospholipase A2 (sPLA2) binds to and hydrolyzes cell membranes. It is important in inflammatory responses and diseases including septic shock, atherosclerosis, and cancer. Normally, cells resist the enzyme’s action, but they become susceptible early during the process of either biochemically-programmed or […]
Search Results for: cancer
Development of Real-Time Polymerase Chain Reaction (q-PCR) Assays for the Specific Detection and Characterization of Select Bacterial Pathogens
Dr. Richard Robison, Department of Microbiology & Molecular Biology The Specific aims for the project were as follows Develop q-PCR reactions for specific target genes of bacterial pathogens Primer generation software will be used to design primer and probe sequences that will theoretically perform optimally in PCR reactions. All sequences will be subjected to BLAST […]
Cytokine Signaling in the Microenvironment May Aid in Tumor Development and Progression
Dr. Kim O’Neill, Department of Microbiology and Molecular Biology Studies have indicated that in breast tumors a high number of tumor associated macrophages (TAM’s) is indicative of a poor prognosis. TAM’s in the breast tumor microenvironment generally have a compromised immune response and focus their energy toward tissue repair which leads to angiogenesis, tumor growth, […]
BYU Students identify Genetic Factors that Modulate Cerebrospinal Fluid Protein Levels and Influence Risk for Alzheimer’s Disease
Dr. John Kauwe, Department of Biology Project Justification and Overview Successful enrollment in and completion of graduate programs requires a constellation of skills. Students must be prepared to plan and execute experiments, present their findings both verbally and in manuscript form and interact effectively with senior scientists in the field of their choice. In this […]
Spin Properties of Electrons in the Semiconductor Gallium Arsenide (GaAs)
Dr. John Colton, Department of Physics & Astronomy Proposed Research The proposed project was to study spin properties of electrons in the semiconductor gallium arsenide (GaAs). Four specific experiments were discussed: Optically-detected magnetic resonance of single quantum dots Parallel picosecond single qubit operations Optically-detected magnetic resonance of spin-LEDs Universal scheme for optically-detected spin flip lifetime […]
Down Syndrome Pathway Analysis
Dr. Mark Clement, Department of Computer Science Many of the most serious medical problems that plague humanity are caused by problems in the genetic regulatory network. Heart disease, cancer and many other maladies could be cured if we understood how genes interact with each other in order to produce different symptoms. Many of these problems […]
Changes in Membrane Physical Properties during Chemotherapy
Dr. John Bell, Department of Physiology & Developmental Biology Abstract of original proposal Many chemotherapeutic agents treat cancer by inducing programmed cell death (apoptosis) in the tumor. One of the consequences of apoptosis is changes in the physical properties of the cell membrane. Some of these changes are important for other phagocytic cells to recognize […]
History of the Church in Brazil
Dr. Mark Grover, Harold B. Lee Library During the months of April and May, 2010, a project to document the history of the LDS Church in the state of Rio Grande do Sul, Rio de Janeiro, and Minas Gerais, Brazil was undertaken. The project was directed by Mark L. Grover and financed by a Mentor’s […]
How Does the Effect of Cholesterol Vary between the Inner and Outer Membrane?
Dr. John Bell, Department of Physiology and Developmental Biology Summary This proposal was designed to use fluorescence spectroscopy to identify in as much detail as possible physical properties of model membranes in effort to understand roles of cholesterol in biological membranes. The following questions were addressed: how does the effect of cholesterol differ between the […]
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The Journal of Undergraduate Research contains published research reports resulting from undergraduate mentoring. Reports are published 1 year after the grants are awarded. (e.g. Reports for projects marked 2013 (projects that were funded in February 2013) were published in January 2014.) activity affect american analysis approach art assessment based behavior byu cancer care cells change […]
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