Brianna Teerlink and Dr. Chin-Yo Lin, Microbiology and Molecular Biology Breast cancer is the second-leading cause of cancer deaths in women in the United States and affects millions each year. Much of the current research on hormonal regulation in breast cancer systems focuses on up-regulation of genes (increased rates of transcription) by estrogen receptors (ERs); […]
Inflammation: A Key Component of the Immunosuppression Observed in Aggressive Breast Cancer?
Bryan Swanson and Dr. Kim O’Neill, Microbiology and Molecular Biology Chemotherapy, surgery, and radiation are current treatments used to combat cancer. Future treatments may directly involve the cancer patient’s immune system. The immune system has the potential to destroy tumors. This destructive potential is orchestrated by small secreted proteins called cytokines and chemokines. These proteins […]
Mice show Decreased Muscle Strength bearing a Targeted Inactivation of nBmp2
Alina Schmidt and Dr. Laura Bridgewater, Microbiology and Molecular Biology An important secreted growth factor, bone morphogenic protein 2 (Bmp2), is involved in mesoderm formation, heart development, neurogenesis, skeletal development, axis formation, and muscle development 1 and is a member of the TGF-β superfamily of proteins. Members of the TGF-β superfamily are commonly known as […]
ACETAMINOPHEN INDUCED DNA DAMAGE EVALUATED WITH THE SINGLE CELL GEL ASSAY
Karl A. Kirby and Dr. Kim L. O’Neill, Microbiology Acetaminophen is a popular non-prescription analgesic and antipyretic drug. Therefore, studies concerning its effects on human DNA are of great value. In this study, the single cell gel, or comet assay, was used to study the extent of Acetaminophen induced DNA damage at varying concentrations and […]
Inflammation and Apoptosis in Developing Dmm, cho, and sedc Articular Cartilage: The Role of the Unfolded Protein Response (UPR)
Caitlin Nichols and Dr. Laura Bridgewater, Department of Microbiology and Molecular Biology Purpose The purpose of this study was to determine whether the Dmm, cho, and sedc mutations in mice collagen genes activate unfolded protein response (UPR) pathways in developing cartilage tissues. The inflammation or cell death triggered by the UPR may contribute to the […]
Chemical Susceptibility of High-risk Native Human Papilloma Virus Virions
Jordan Meyers and Dr. Richard Robison, Microbiology and Molecular Biology This project was designed to take an in-depth look into how resistant papilloma viruses are to common clinical disinfectants. This idea was investigated because there is no published data on papillomavirus. Many other non-enveloped viruses (viruses that do not have a membrane) like poliovirus and […]
Understanding the phoU Protein’s Part in Phosphate Import by Synthesis of Double Mutations in Escherichia coli.
Geoffrey R. Johnston and Dr. William McCleary, MMBIO The purpose of our research was to gain a better understanding of what function the phoU protein serves in phosphate import by completely knocking out it’s functionality at two highly conserved and nearly identical sites on almost identical domains at a genetic level. All of the known […]
Identification and Characterization of an Effective Antimicrobial Peptide Defensin and its Effects on Transmission Efficiency
Kody Johnson and Dr. David Erickson, Department of Microbiology and Molecular Biology Among many transmissible infectious diseases falls the Bubonic Plague, a disease that is caused by Yersinia pestis, a bacterium. It is still a concern because there have been human cases as recent as two years ago in our home state of Utah. While […]
The Influence of the IRF 5 Risk Haplotype on EBV Gene Expression in B Cells
Brandon Henrie and Dr. Brian Poole, Dept of Microbiology and Mol. Biology Introduction IRF5 (interferon regulatory factor 5) is an integral protein in the innate immune response to viruses in humans. Once activated, IRF5 acts as a transcription factor which facilitates the production of inflammatory cytokines, interferons, and a host of other anti-viral agents in […]
A Functional Assay to Measure Chemokine Mediated Integrin Upregulation
Victoria Harris and Dr. Eric Wilson, Department of Molecular Biology and Microbiology The presence of IgA antibody secreting cells (ASCs) in mucosal tissues is a mechanism of host defense against many pathogens. For my project I investigated the molecular mechanisms of how these specialized cells arrive at their destination. I focused on designing an adhesion […]
- « Previous Page
- 1
- …
- 23
- 24
- 25
- 26
- 27
- …
- 31
- Next Page »