Kody Johnson and Dr. David Erickson, Department of Microbiology and Molecular Biology Among many transmissible infectious diseases falls the Bubonic Plague, a disease that is caused by Yersinia pestis, a bacterium. It is still a concern because there have been human cases as recent as last year in our home state of Utah. While health […]
Twinkle Primase/Helicase Protein in Arabidopsis thaliana
Travis Hunt and Dr. Brent Nielsen, Microbiology and Molecular Biology The overall goal of the project was to study the role of DNA recombination in maintenance of plant mitochondrial DNA (mtDNA). Recombination is the process by which a molecule of DNA is nicked or broken and then the end is joined to a different but […]
BMP2 Nuclear Variant and Expression of Cancer Genes
Devin Holden and Dr. Laura Bridgewater, Microbiology and Molecular Biology Bone morphogenic protein 2 (BMP2) is a protein that is secreted outside many different types of mammalian cells and has been implicated in the pathogenesis of various forms of cancer. Recently, a variant of this protein that is localized to the nucleus (nBMP2) of the […]
Lymphocyte Apoptosis in the Involuting Mammary Gland and the Application of qPCR in Gene Expression Profiling
Kathryn Distelhorst and Dr. Eric Wilson, Microbiology and Molecular Biology The initial aim of this project was to discover the fate of lymphocytes in the mammary gland after lactation. I hypothesized that lymphocytes, in an analogous mechanism used by mammary gland-specific epithelial cells, undergo apoptosis, or programmed cell death. This non-inflammatory mechanism ensures cell homeostasis, […]
FeuN as a Regulator in a Two Component System
Rebecca Carlyon and Dr. Joel Griffitts, Microbiology and Molecular Biology How does infection work? There exists a process in which a bacterium receives a signal from the environment which starts a series of events which initiates infection. This process is vital for understanding both disease-causing and beneficial bacteria, and could prove to be vital for […]
Identification of Insertion Points of the Macrophage Fas-Induced Apoptosis (Mafia) Transgene
Robert E. Brown III and Dr. Sandra Burnett, Ph.D., MMBio Problem Without site direction, transgenes integrate randomly into the genome of target cells. The transgene used in macrophage fas-induced apoptosis (Mafia) mice was randomly incorporated and indications of multiple insertion sites were observed. Our goal in performing this study was to detect the exact insertion […]
A Nuclear Variant of Gdf5 may present Novel Insights on Arthritis Formation
Michael Baldwin and Dr. Laura Bridgewater, Department of Microbiology and Molecular Biology More than 40 million Americans suffer from the pains of arthritis. Arthritis is characterized by joint inflammation and cartilage deterioration (3). For many years growth differentiation factor 5 (Gdf5) has been associated with cartilage formation and maintenance (4, 1). Recently, a new variant […]
Mutant Bacterium Photorhabdus Luminescens’ Effect on Nematode’s Ability to Enter Endotokia Matricida
Jared Nielsen and Dr. Byron Adams, Microbiology and Molecular Biology Nematodes (roundworms), like all organisms, must develop, survive, and reproduce. For entomopathogenic nematodes (insect pathogens) such as H. bacteriophora, this is only possible when the worm can find an adequate food source (host insects). As the nematode scours the surrounding soil and finds a potential […]
MECHANISMS OF ESTROGEN RECEPTOR α MEDIATED TRANSCRIPTIONAL REPRESSION
Joseph Sin, Molecular Biology In the US, the American Cancer Society estimates that in 2008, breast cancer killed 40,930 people. Breast cancer remains the most common form of cancer among women today and results in almost 1% of all deaths worldwide. Various types of treatment for breast cancer exist today such as surgery, chemotherapy, radiotherapy, […]
PCR Genotyping and Analysis of Bacteriocin Production by Natural Salmonella Isolates for Potential Use as Inhibitors of Pathogenic Salmonella
Ramesh Tiwari and Dr. Brent Nielsen, Micro and Molecular Biology Salmonella is a genus of bacteria that is a major cause of food borne illness throughout the world. Species of Salmonella like S. thyphimurium and S. enteriditis still pose significant health problems. Poultry and egg products are the main food sources infected by these species […]
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