Kathryn Distelhorst and Dr. Eric Wilson, Microbiology and Molecular Biology The initial aim of this project was to discover the fate of lymphocytes in the mammary gland after lactation. I hypothesized that lymphocytes, in an analogous mechanism used by mammary gland-specific epithelial cells, undergo apoptosis, or programmed cell death. This non-inflammatory mechanism ensures cell homeostasis, […]
Molecular Modeling and Dynamics: Development of a model for the glcosphingolipid GT1b
Dustin Danowski and Professor David Busath, Department of Physiology and Developmental Biology Botulinum Neurotoxin (BoNT) is currently being widely researched a a possible treatment for many medical conditions, as well as for cosmetic purposes. However, the mechanism describing how this family of toxins interact with their receptors to cause endocytosis is not well understood. We have developed […]
Modifying the Apical Ectodermal Ridge in Embryological Development of Vertebrates
Lauren Clough and Dr. Jeffery R. Barrow, Physiology and Developmental Biology Introduction Vertebrate embryonic limb development is a complex process that involves many genes and processes. Patterning takes place along three axes, including the proximal-distal axis of the limb. The Apical Ectodermal Ridge (AER) helps to guide development along the proximal-distal axis, but the genetic […]
Iron Impregnated Elemental Sulfur Application to Kentucky Bluegrass: Comparison of Standard Fertilizer Methods
Ryan Christensen and Dr. Bryan G. Hopkins, Plant and Wildlife Science Landscape managers spend substantial resource, both time and money, maintaining aesthetically pleasing landscapes. In addition, athletic events conducted on natural grass playing surfaces are dependent upon having a healthy turfgrass that provide both cushioning and footing stability. Poor field conditions can lead to career […]
Discovering the Involvement of Lipid-Rafts in the Interleukin-6 Pathway of Cortisol Release from Adrenal Cells
Timothy Chang and Dr. Allan M. Judd, Physiology and Developmental Biology Cortisol is a steroid hormone produced by the adrenal cortex and is involved in response to stress and increases blood pressure, blood sugar levels, suppresses the immune system, and may cause infertility in women. The pathway in which protein Interleukin-6, also known as IL-6, […]
FeuN as a Regulator in a Two Component System
Rebecca Carlyon and Dr. Joel Griffitts, Microbiology and Molecular Biology How does infection work? There exists a process in which a bacterium receives a signal from the environment which starts a series of events which initiates infection. This process is vital for understanding both disease-causing and beneficial bacteria, and could prove to be vital for […]
Determining and Sharing Knowledge about Phylogenetic Relationships of Collomia Species (Mountain-trumpet Flowers)
Lisa Busby and Dr. Leigh Johnson, Life Science The plant genus Collomia shows great morphological and genetic diversity, however, its current classification is based on a morphological study done in 1940. This year I was able to assemble a great deal of DNA sequence information and compare the variation in these sequences with previous classifications […]
Life Histories of Brook Trout (Salvelinus fontinalis) and their Replacement of Cutthroat Trout (Oncorhynchus clarki)
Amy Burgess and Dr. Dennis Shiozawa, Department of Biology The cutthroat trout (Oncorhynchus clarki) is a member of the Salmonid family native to the western North America. Brook trout (Salvelinus fontinalis) is also a member of the salmonid family but a native to eastern North America, but has been introduced into many areas in western […]
Genetic Diversity of Native Utah Flora
Benjamin Brulotte and Dr. Mikel Stevens, Plant and Wildlife Sciences Amplified fragment length polymorphisms are a reliable, straightforward method of determining the genetic diversity of species. Frequently this method of determining genetic diversity has been used in conservation efforts because of its cost effectiveness, and efficiency. We set out to characterize the genetic diversity of […]
Identification of Insertion Points of the Macrophage Fas-Induced Apoptosis (Mafia) Transgene
Robert E. Brown III and Dr. Sandra Burnett, Ph.D., MMBio Problem Without site direction, transgenes integrate randomly into the genome of target cells. The transgene used in macrophage fas-induced apoptosis (Mafia) mice was randomly incorporated and indications of multiple insertion sites were observed. Our goal in performing this study was to detect the exact insertion […]
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