Stewart Morley and Dr. John Prince, Department of Chemistry & Biochemistry Introduction Proteomics uses highly sensitive mass spectrometers to measure peptide fragment masses from enzymatically digested proteins. Measuring the mass of the peptide and fragments produced in the mass spectrometer allows for identification of its parent protein. Phosphoproteomics analyzes peptides that have been phosphorylated. Phosphoproteomics […]
Lipidomic Analysis of Metastatic Kidney Cancer
Brendan Coutu and Dr. John Prince, Department of Chemistry and Biochemistry Introduction Cancer not only affects individuals and families but has the greatest economic effect worldwide than any other premature cause of death.1 Diverse aspects of cancer biology are under investigation to better understand the mechanism of action of different cancer types, that biomarkers can […]
TRANSLATIONAL CONTROL OF POLY(A)-BINDING PROTEIN EXPRESSION
Eliott Spencer and Dr. Roger Kaspar, Chemistry Poly(A)-binding protein or PABP is found in high concentrations in all eukaryotic cells. Cell biologists have speculated for a long time that PABP plays an important role in stabilizing the fragile MRNA molecule so that it can be more effectively translated into its final gene product. PABP does […]
INVESTIGATE THE FUNCTION OF THE 5′ LEADER IN THE HUMAN AT1 ANGIOTENSIN RECEPTOR
Erik J. Petersen and Dr. Terry S. Elton, Chemistry and Biochemistry A comparison of several published hAT1R cDNA sequences revealed that, although these clones shared an identical open reading frame, they differed in portions of their 5′-UTRs.1 Therefore these data suggest that alternative splicing events combine various 5′-UTR exons with the exon that harbors the […]
Enantioselective Synthesis of Hasubanan Alkaloids
Daniel and Laura Nielsen with Dr. Steven L. Castle, Chemistry and Biochemistry In nature, many molecules exist in two different forms, referred to as enantiomers. These forms are structurally identical, yet they are mirror images of each other. One simple example of this is our hands. While both hands are structurally identical, there is no […]
The Planar Ion Trap
Ivan Miller and Dr. Daniel Austin, Chemistry and Biochemistry Mass spectrometry has been a common analytical procedure for over fifty years. Today it is most commonly used to characterize and quantify unknown solutions, solids, and vapors in chemical and biochemical environments by determining the specific masses of atoms and molecules. Ion traps have become standard […]
Investigation of the Structure of Quinoa Saponins by HPLC and MASS-SPEC
Samuel Swainhart and Dr. Steve Wood, Dept. of Chemistry & Biochemistry Quinoa is a grain grown mainly by Natives in diverse areas throughout Latin America that is considered by many nutritional scientists as possibly the most nourishing grain available. Its contents include high levels of protein, an exceptional composition of amino acids, and many carbohydrates. […]
REDOX PROPERTIES OF HORSE SPLEEN FERRITIN
D. Cope Norcross and Dr. Gerald D. Watt, Chemistry and Biochemistry Iron is essential to all forms of life. Yet, free iron is toxic unless sequestered and regulated. Organisms use the protein ferritin to perform this function. Ferritin is found storing and releasing iron in almost all living organisms. Ferritin is a large, nearly spherical, […]
APPLICATIONS OF META 1,3-PHOTOCYCLIZATIONS USING SILICON AS A TETHER
Bradley Nilsson Current literature contains many examples of the use of light to induce the synthesis of novel compounds and natural compounds. One reaction that has been extensively studied is the meta photocycloaddition of arenes to alkenes. Commonly this is experimentally treated as an inten-nolecular reaction. Problems with this approach to the photocycloaddition include low […]
LITHIUM-HALOGEN EXCHANGE IN NON-ETHEREAL SOLVENT: EFFICIENT PREPARATION OF 2-BROMO-6-LITHIOPYRIDINE IN DICHLOROMETHANE
Jared R. Mitchell and Dr. Matt A. Peterson, Chemistry and Biochemistry Organolithium reagents have long been known as useful reagents for carbon-carbon bond formation in synthetic organic chemistry. Although a variety of techniques have been developed for their generation, one of the most frequently used methods involves treating either an alkyl or aryl halide (R-X, […]
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