Erik J. Petersen and Dr. Terry S. Elton, Chemistry and Biochemistry A comparison of several published hAT1R cDNA sequences revealed that, although these clones shared an identical open reading frame, they differed in portions of their 5′-UTRs.1 Therefore these data suggest that alternative splicing events combine various 5′-UTR exons with the exon that harbors the […]
Mechanism of Translation Termination
Michael Pfeiffer and Dr. Allen Buskirk, Chemistry and Biochemistry Background Each cell within our body contains thousands of different kinds of proteins, each with a different function. Proteins provide cellular structure and perform catalysis of chemical reactions in the cell. Every protein is synthesized as ribosomes link together amino acids in the order encoded by […]
Thermodynamic Properties of Nanoalumina Synthesis and Analysis of Nanoalumina
Rebecca Olsen and Dr. Juliana Boerio-Goates, Chemistry and Biochemistry Nanomaterials, possessing unique chemical, physical, and mechanical properties, can be used in a wide range of industrial, biomedical, and electronic applications. There are three general categories for producing nanomaterials: mechanical processing (milling), chemical processing (precipitation), or thermal processing (evaporation and condensation). Conventional methods often have drawbacks […]
Enantioselective Synthesis of Hasubanan Alkaloids
Daniel and Laura Nielsen with Dr. Steven L. Castle, Chemistry and Biochemistry In nature, many molecules exist in two different forms, referred to as enantiomers. These forms are structurally identical, yet they are mirror images of each other. One simple example of this is our hands. While both hands are structurally identical, there is no […]
A Trojan horse approach to cancer treatment: A2DA and A2NOON as Potential Triggered and Targeting Chemotherapeutic Drugs
Jeremy Koontz and Dr. Heidi Vollmer-Snarr, Chemistry and Biochemistry Despite the enormous amounts of time and money spent to research effective cures for cancer—the second leading cause of death in the United States —little is known today about how to kill cancer cells without harming normal cells. Current traditional forms of cancer treatment are chemotherapy, […]
Does the Ribosome Cleave mRNA? Searching for the A-site Endonuclease
Jeremy Goodson and Dr. Allen Buskirk, Chemistry and Biochemistry Trans-translation can be broken down into 5 steps. , After a ribosome stalls, the mRNA in its aminoacyl-tRNA site (A-site) is cleaved and released, which leaves the A-site empty. The key molecule in ribosomal rescue, transfer-messenger RNA (tmRNA), then forms a complex with Small Protein B […]
Covalent Modification of Hydrogen-terminated Silicon Surfaces through a One-step Polymerization Process
Robert Blake and Dr. Matthew R. Linford, Chemistry and Biochemistry Silicon is one of the most abundant elements on the earth and has been used throughout history in a variety of applications. Because silicon is so widely used in the semiconductor and electronics industries, recent research has focused on altering the properties of silicon wafers. […]
Ectodermal Dysplasia in Family Arises from Unidentified Dominantly Inherited de novo Mutation
Phil Young and Dr. Emily Bates, Chemistry and Biochemistry Introduction Ectodermal dysplasia (ED) is a genetic disorder dealing with improper formation of tissues derived from the ectoderm, such as skin and sweat glands. Many clinical manifestations of the disorder exist, which has led to the classification of over 170 types of ectodermal dysplasia (1). The […]
Dominantly Inherited Mutation of Ectodermal Dysplasia
Ella Wyllie and Dr. Emily Bates, Biochemistry Introduction Ectodermal Dysplasia is a genetic disorder associated with the abnormal development of hair, teeth, nails, tear ducts, sweat glands, and occasionally gross craniofacial or digit structure. ED is caused by a defective in the growth and development of the ectoderm where their tissues are derived. There are […]
Does PEGylation Increase the Thermodynamic Stability of the WW domain of Pin1 via Hydrogen Bonding? A Molecular Dynamics Simulation
Chad Torgerson and Dr. Joshua Price, Department of Chemistry and Biochemistry Introduction Proteins are complex molecules that have the potential to treat diseases and illnesses that small molecule drugs cannot. However, a significant problem with protein medications is that proteins tend to have short serum half-lives and can be difficult to store for extended periods […]
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