Lauren Zagieboylo and Dr. Eric Wilson, Microbiology and Molecular Biology Main Text B-1 B cells are an understudied type of white blood cell that provide T cell-independent antibody production, allowing them to play an important role in the early immune response to many bacterial and viral pathogens. They are especially important for defense in mucosal […]
Inhibition of Notch Signaling Increases Neurogenesis in the Ophthalmic Trigeminal Placode without Expanding the Domain of Neurogenin2 Expression.
Brian Wright and Dr. Michael Stark, Physiology & Developmental Biology The ever-increasing knowledge regarding cellular regulation and programming requires important insights into the biochemical pathways that determine a cell’s fate. For example, the ability to take a stem cell and grow it into a neuron will directly depend on our knowledge of the steps used […]
Isolating Mononucleosome Core DNAs To Be Used in the ENCODE Project
Elliot Winters and Dr. Steven M. Johnson, MM Biology Main Text The purpose of this project has its roots in the nationwide mission named “ENCODE” for the “ENCyclopedia Of DNA Elements” the purpose of which is to map the functional elements of the human genome. The human genome was successfully sequenced in 2001, (Consortium T.I.H.G.S., […]
The Role of RAGE in Inflammatory Lung Disease Induced by Diesel Particulate Matter
Karisa Wasley and Dr. Paul Reynolds, Physiology and Developmental Biology Main Text The causes of high morbidity and mortality associated with inflammatory respiratory diseases are not well understood. My research project helped to shed light on cellular signaling pathways associated with inflammatory disease, particularly those caused by or worsened by air pollutants. Asthmatics, in particular, […]
Function of Novel Nuclear-Variant Bone Morphogenic Protein (nBMP2) In Muscle Fiber Type Differentiation
Nicholas Wallace and Dr. Laura Bridgewater, Microbiology & Molecular Biology Bone morphogenetic proteins (BMPs) are in the transforming growth factor B (TGF-) super family of proteins, which were originally identified by their ability to induce bone formation in animals.A novel nuclear variant of BMP2 (nBMP2) was recently discovered by Dr. Bridgewater and her graduate researchers. […]
Preparing For Research: Seeing From a New Viewpoint
Deborah Thompson-Rigby and Dr. Zachary Aanderud, Plant and Wildlife Sciences Learning how to conduct research is vital if one plans to continue doing research past their undergraduate degree. In the near future I will be starting a masters degree where I will really learn the ins and outs of research, but the preparation needed to […]
Identification of Yersiniapseudotuberculosisgenes that affect Congo-red binding
Ryan Stewart and Dr. David Erickson Abstract The plague bacterium Yersiniapestisrecently evolved from the enteric pathogen Yersiniapseudotuberculosis, during which time it has adopted a flea-borne lifestyle. Y. pestisforms a biofilmin the flea digestive tract to enhance transmission, whereas Y. pseudotuberculosisdoes not. Biofilmformation requires the hmsgenes, which direct the production of an N-acetylglucosamineextracellular matrix (ECM) that […]
PAS Kinase Interactions
Steven Sowa and Dr. Julianne Grose, Microbiology Goal To discover the substrates of PAS kinase. Introduction Signal transduction pathways are critical to the function of a cell. Correct signals help the cell to manage its resources effectively while improper or inactive signals contribute to cancer and many other human diseases. One protein involved in signal […]
The Misapplication of DNA Barcodes to Taxonomic Classification
Taylor Southwick and Dr. Keith Crandall, Department of Biology Main text The classification of organisms into different taxa is a central issue in biology. If similar organisms are grouped together, then comparative analyses can be used from the genome to the systems level to understand how they work, both biologically and behaviorally. There are two […]
Ror2/Wnt5a Mediated Directional Limb Outgrowth
Aaron Smith and Dr. Jeff Barrow, Physiology and Developmental Biology The apical ectodermal ridge (AER) is a small strip of epithelial tissue that is found at the distal tip of the embryonic vertebrate limb and runs from anterior to posterior. It is known that the AER is necessary to maintain the life of mesenchymal cells […]
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