Dr. John Bell, Department of Physiology & Developmental Biology Abstract of original proposal Many chemotherapeutic agents treat cancer by inducing programmed cell death (apoptosis) in the tumor. One of the consequences of apoptosis is changes in the physical properties of the cell membrane. Some of these changes are important for other phagocytic cells to recognize […]
Receptors for Advanced Glycation End-Products (RAGE) Mediates Particulate Matter-Induced Pulmonary Inflammation
Dr. Paul Reynolds, Department of Physiology & Developmental Biology Academic Objectives Met and Results Observed Funding available through this MEG award has provided an opportunity for me to meet many academic objectives I’ve determined to be important in the early stages of my faculty appointment at BYU. First of all, I have been able to […]
Soluble Epoxide Hydrolase is Down-Regulated in the Brains of Female HS Rats compared to NS Rats
Dr. James Porter, Department of Physiology & Developmental Biology Specific Question 1. Can the down-regulation of epoxide hydrolase expression determined by microarray analysis be confirmed using RT-PCR? We were able to use RT-PCR to confirm that mRNA expression for brain soluble epoxide hydrolase was significantly down-regulated. The magnitude of relative down-regulation was on the same […]
How Does the Effect of Cholesterol Vary between the Inner and Outer Membrane?
Dr. John Bell, Department of Physiology and Developmental Biology Summary This proposal was designed to use fluorescence spectroscopy to identify in as much detail as possible physical properties of model membranes in effort to understand roles of cholesterol in biological membranes. The following questions were addressed: how does the effect of cholesterol differ between the […]
Role of AMP Kinase in the Regulation of Cortisol Release From the Adrenal Gland
Dr. Allan M. Judd, Department of Physiology and Developmental Biology Evaluation of how well the scholarly objectives of the proposals were met Throughout the three years the funding of this proposal was utilized , I (Dr. Judd) have weekly laboratory meetings and journal clubs for undergraduate and graduate students in the laboratory. At the journal […]