David Morris and Dr. Keith Crandall, Department of Biology Evolutionary Biology is not a branch of biology that spends much time in the public eye. It just doesn’t have flashy results like cloning or evocative naturalist documentaries to captivate the imagination. However, this doesn’t mean that evolutionary biology is any less essential to our understanding […]
What Fatty Acids in Dairy Cow Feces may Predict Resistance or Susceptibility to Production-Related Metabolic Diseases
Brian Melville and Professor Beverly Roeder, Department of Biology Dairy cows supply an important food source for humans, and any disease that hurts production threatens this source. Once a cow has a PRMD (production related metabolic disease) there are many signs and symptoms that are readily observed and tested for, but it would be useful to […]
Does Secretory Phospholipase A II Induce Apoptosis in Cells that have been Infected by a Virus?
Stephanie Melchor and Dr. John Bell, Department of Physiology and Developmental Biology Well, to be perfectly honest, this project has been fraught with disaster since the beginning. We obtained 400 microliters of the immunosuppressive strain of Minute Virus of Mice (MVMi) at 1 x 109 pfu/mL from Dr. David J. Pintel at the University of […]
How ‘bout them Apples?: A Study on Antioxidants
Kylie Measom and Dr. Kim O’Neill, Department of Microbiology and Molecular Biology They say “an apple a day keeps the doctor away.” Apples are laden with antioxidants which have been shown to prevent against cancer and other illnesses.1 Antioxidants are molecules that prevent cancer by collecting excess free radicals in the body. Free radicals are […]
The Effect of Male Dominance on Female Mate Choice in Poecilia gillii
Michael McEntire and Dr. Jerald Johnson, Department of Biology Research Summary Female mate choice (intersexual selection) and male dominance interactions (intrasexual selection) can each play important roles in sexual selection. These two mechanisms tend to be discussed in isolation. The goal of this study is to explore the interaction between these two forms of sexual […]
Effects of Acetyl-L-carnitine Supplementation on AMPK-Activity and Mitochondrial Biogenesis in LKB1 Knockout Mice
Lisa McCoy and Dr. David Thomson, Department of Physiology and Developmental Biology During the medical school interview of the school I will be attending next Fall, my interviewer asked me to speak of a time in which I had failed or suffered an obstacle in my academic career. He laughed and said that I probably […]
Effects of AntiViral Drug Compounds in Blocking Influenza Virus M2 Channels in Xenopus Laevis Ooctyes
Timothy McClain and Professor David Busath, Department of Physiology and Developmental Biology Goal/Purpose of the Project The purpose of this project was to research and test various drug compounds to prevent influenza virus infection. A specific target of my research is M2 protein channels that aid in the uncoating of the viral coat. Recent mutations have rendered formerly […]
Characterizing Proteins that Interact with PAS Kinase
Jordan Mackay and Dr. Julianne Grose, Department of Microbiology and Molecular Biology Characterizing the interacting protein partners of Per-Arnt-Sim (PAS) kinase has proven to be a formidable task. Since the beginning of 2012, I have been working hard with graduate student Desi DeMille on confirming the putative interactors uncovered by genetic screening done the previous […]
The Spondyloepiphyseal Dysplasia Congenita homozygous Mutant: A Model for the Mechanism of Osteoarthritis
David Macdonald and Dr. Robert Seegmiller, Department of Physiology and Developmental Biology Articular cartilage is a hard-wearing and specialized form of hyaline cartilage which allows for an almost frictionless surface during joint movement (Ofek et al. 2008). These unique characteristics are primarily due to chondrocyte secretions, and the composition and properties of the extracellular matrix (ECM) (Buckwalter and […]
EBI2 Knockdown and Effects on B-Cell Migration
Jordan Mabey and Dr. Brian Poole, Department of Microbiology and Molecular Biology Introduction B cells are specialized cells which participate in the normal immune response to an infection. As B cells encounter antigens in the body, they become activated and travel to what is known as a B cell follicle within a lymph node. At […]
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