David Michaelis – Department of Chemistry and Biochemistry Evaluation of how well the academic objectives of the proposal were met The main objectives of this proposal was to publish our preliminary findings in peptide catalysis and then submit applications for external funding. Both of these objectives were accomplished during the grant period. In the Fall […]
Search Results for: synthesis
Mentoring Undergraduates at the Intersection of Organic Synthesis and Peptide Science
PI: Steven L. Castle Introduction This report summarizes the results that were generated under the auspices of the mentoring environment in my laboratory from January 2015 to the present. A total of ten undergraduates participated in the mentoring environment during this period. Their names and accomplishments are listed below. Evaluation of Academic Objectives Our academic […]
The total synthesis of yaku’mide A
Luo, Shi The total synthesis of yaku’amide A Faculty Mentor: Steven Castle, Department of Chemistry and Biochemistry Yaku’amide A (YA) has potent toxicity against cancer cells (IC50 = 14 ng/ml against P388 murine leukemia cells). Ueoka et al.1 first reported the isolation of YA from a marine sponge in the East China Sea. They used […]
Effects of muscle cooling on AMPK and protein synthesis in skeletal muscle
Lyons, Kyle EFFECTS OF MUSCLE COOLING ON AMPK AND PROTEIN SYNTHESIS IN SKELETAL MUSCLE Faculty Mentor: David Thomson, PDBIO Background AMP-activated protein kinase (AMPK) is an intracellular protein that regulates many signaling responses including the mechanistic target of rapamycin (mTOR) pathway, which increases protein synthesis1. Recent research suggests that cold-water immersion of the leg activates […]
Integration Host Factor Stabilized PCR- amplified DNA for High-Throughput Protein Synthesis Subtitle
William Bradley Faculty Mentor: Bradley Bundy, Dept. of Chemical Engineering Introduction As the search continues for novel proteins with market-incentivized properties, the demand for tools to accelerate the identification of these proteins increases. This has led to investigating methods for screening proteins that yield faster results (high-throughput) with greater titers of protein stable enough for […]
Organic Synthesis as a Platform for Mentoring Undergraduates
Steven L. Castle, Department of Chemistry and Biochemistry Introduction This report summarizes the results that were generated under the auspices of the mentoring environment in my laboratory from January 2014 to the present. A total of six undergraduates participated in the mentoring environment during this period. Their names and accomplishments are listed below. Evaluation of […]
Mentoring Undergraduates Via Organic Synthesis
Steven L Castle, Department of Chemistry and Biochemistry Introduction. This report summarizes the results that were generated under the auspices of the mentoring environment in my laboratory from January 2013 to the present. A total of eight undergraduates participated in the mentoring environment during this period. Their names and accomplishments are listed below. Evaluation of […]
Design and Synthesis of (-)- Englerin A Mimics
Kayleen Thompson and Dr. Merritt Andrus, Chemistry and Biochemistry Englerin A, which comes from an East African plant, Phyllantus englari, has been found to be an impressive anti-renal cancer agent. It is even more promising than another leading natural anticancer agent, Taxol.1 Englerin A has a unique, complex structure, and its exact mode of action […]
Synthesis and Purification of the Glycosphingolipid CSA-13
Tyler Olsen and Dr. Paul Savage, Department of Chemistry and Biochemistry The need for novel antibiotic mechanisms is prevalent. Common antimicrobial medicines such as penicillin, ampicillin and vancomycin have started becoming obsolete as resistant strains of bacteria become more widespread. The main problem with antibiotics is the rapid mutations that bacteria undergo. Eventually one cell […]
Synthesis of S-Equol using Heck Coupling Reaction and Phase-Transfer Catalysis
Chelsey Hancock Please list all accomplishments, achievements, publications, presentations, or other scholarly productivity that resulted from your ORCA project. This may include submissions to peer-reviewed journals, conference presentations or papers, performances, exhibitions, internships, scholarships, graduate school opportunities, local presentations, or awards that followed your mentoring experience. Through this ORCA grant, I was able to present […]
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