Adam Wynn, Jeffery Tessem, Ph.D. Nutrition, Dietetics, and Food Science Progression to type 2 diabetes (T2D) includes a loss of functional pancreatic beta cells (β-cells), which are responsible for secreting insulin and maintaining healthy blood sugar levels. Nr4a1 is a gene that has been shown to be involved in fuel utilization in the liver, muscles, and […]
Search Results for: role
The Role of Nrf2 In Prevention of Oxidative Stress Caused by Valproic Acid
Madison Wilson and Jason M. Hansen, Physiology & Developmental Biology Introduction Valproic acid (VPA) is a common drug used to treat epileptic seizures as well as bipolar disease. Over the past decade, the use of these drugs has increased dramatically as they are now being prescribed as antipsychotics, mood stabilizers, and are currently being tested […]
Chemokine Receptor CCBP2-V41A and its Role in Inflammation and Alzheimer’s Disease
Allen Weinert and Scott Weber, Microbiology & Molecular Biology Introduction The leading cause of dementia in elderly patients is Alzheimer’s disease (AD), a degenerating and fatal neurodegenerative condition. AD is a proteopathic disease caused by extensive accumulation of amyloid beta plaques and neurofibrillary tangles. A recent genomewide association study analyzing 59 AD-associated cerebrospinal fluid (CSF) […]
Determining the Role of CD5 in regulatory T Cell Function
Charles Teames and Scott Weber, Microbiology & Molecular Biology Introduction Regulatory T cells (Tregs) inhibit the immune response and play a key role in preventing autoimmunity. Unfortunately, Tregs also often prevent an effective immunological response against cancer. CD5 is a T cell surface protein known to regulate the threshold for T cell activation. CD5 is […]
Role of Electrical Synapses in Dopamine Transmission in the Brain
Josh Nelson, Seth Stapley and Scott Steffensen, Psychology Introduction- Drug addiction has long been a major detriment to society. Its pervasive effects can tear apart the lives of addicted individuals. Many of these individuals go without seeking professional help. In 2015, 22.7 million Americans (8.6 percent) needed treatment for a problem related to drugs or […]
Whole-Genome Sequencing in the Neonatal Intensive Care Unit (NICU): Nurses’ Roles in Communicating Test Results to Families
Laura Grenfell and Deborah Himes, College of Nursing Research Process: The grant I received through the Office of Research and Creative Activities was helpful in supporting this research project. My mentor and I started work on the project early in the year by analyzing the data we had gathered. In 2017, I attended a nursing […]
Characterization of Mutant Chemokine (C-C) motif Receptor-Like 2 (CCRL2) and its Role in Inflammation and Alzheimer’s Disease
Meganne Ferrel and Dr. John S. K. Kauwe, Biology Introduction Alzheimer’s Disease (AD) is identified as a proteopathic disease that results from an extensive accumulation of amyloid plaques and neurofibrillary tangles in the brain. Several researchers have discovered that cerebrospinal fluid (CSF) contains biomarkers for AD such as Amyloid-beta and tau. Neuritic plaques in AD […]
The Role of Inflammation in the Progression of Osteoarthritis
I received funding for this MEG in January of 2015. This was a remarkably fruitful MEG for my lab. The work completed through this grant proposal led to some ground breaking data that translated into two patent applications (Topical/Transdermal application of wogonin for promoting chondrocyte autophagy, leading to reversal of damage associated with osteoarthritis as […]
Painted Ladies of Rome: The Role of Beauty in Defining Female Excellence
Cassandra Ball Faculty Mentor: Michael Pope, Comparative Arts and Letters Ancient Rome was a culture obsessed with excellence, and much scholarly ink has been spent identifying and elucidating the intricate matrix of ideal Roman masculinity. Meanwhile, relatively little scholarly attention has been paid to the concept of feminine excellence, or the means by which Roman […]
Elucidating the Role of the Transcriptional Co-activator camta1 in Cardiac Development
Nate Batey, Zach Frederich, Morgan Fronk, Nate Jenkins and Jonathon Hill, Physiology and Developmental Biology Introduction Congenital Heart Disease (CHD) is the most common type of birth defect in the United States, causing more first-year infant deaths than any other birth defect (1). While the causes of CHD are varied, genetic defects are known to […]
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