Allen Weinert and Scott Weber, Microbiology & Molecular Biology Introduction The leading cause of dementia in elderly patients is Alzheimer’s disease (AD), a degenerating and fatal neurodegenerative condition. AD is a proteopathic disease caused by extensive accumulation of amyloid beta plaques and neurofibrillary tangles. A recent genomewide association study analyzing 59 AD-associated cerebrospinal fluid (CSF) […]
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Characterization of Mutant Chemokine (C-C) motif Receptor-Like 2 (CCRL2) and its Role in Inflammation and Alzheimer’s Disease
Meganne Ferrel and Dr. John S. K. Kauwe, Biology Introduction Alzheimer’s Disease (AD) is identified as a proteopathic disease that results from an extensive accumulation of amyloid plaques and neurofibrillary tangles in the brain. Several researchers have discovered that cerebrospinal fluid (CSF) contains biomarkers for AD such as Amyloid-beta and tau. Neuritic plaques in AD […]
Examining how the CD5 co-receptor alters T helper cell activation in response to bacterial infection
Garrett Hamblin and Faculty Mentor: Scott Weber, Department of Microbiology and Molecular Biology Properly functioning helper T cells are crucial in a response to an infection. The adaptive immune response is orchestrated by T helper cells and their function is dependent upon interactions between the T cell receptor (TCR), peptide MHC (pMHC) and co-receptors. Upon […]
The Involvement of the IP3 Receptor in the Rewarding/Addictive Properties of Methamphetamine
Mark Woodbury and Dr. Scott Steffensen, Neuroscience Department Introduction Methamphetamine (METH) is a very powerful psychoactive drug that is highly addictive and toxic to the brain. Its use and abuse has been rising in recent years, and certain reports indicate that amphetamine-like drugs are the second most abused drugs worldwide. The side effects of METH […]
METH Causes Expression of 8-OHG in the Addiction Pathway and Leads to Increased S-Glutathionylation of the Vesicular Monoamine Transportor Via the Sigma Receptor
Taylor Hyde and Scott Steffensen, Department of Psychology Introduction Methamphetamine (METH) is a highly addictive drug of abuse and which results in serious financial, societal, and individual consequences in the United States. In 2005, METH abuse costs the country billions dollars each year. Societal and individual costs as a result of METH use are also […]
Role of Sigma Receptors in Low-dose Methamphetamine Modulation of Dopamine Release in the Nucleus Accumbens
Marchant, Gilbert Role of Sigma Receptors in Low-dose Methamphetamine Modulation of Dopamine Release in the Nucleus Accumbens Faculty Mentor: Scott Steffensen, Psychology Introduction Methamphetamine (METH) is an addictive drug of abuse and METH use is a growing problem in the United States. The current dogma states that psychostimulants such as METH attack the mesocorticolimbic dopamine […]
Expression Changes of Dopamine Type 2 Receptor on the Surface of Human Monocytes and Lymphocytes After Exposure to Dopamine In Vitro.
Garcia, Brandon Thomas Expression Changes of Dopamine Type 2 Receptor on the Surface of Human Monocytes and Lymphocytes After Exposure to Dopamine In Vitro. Faculty Mentor: Sandra Hope, PhD and Scott Steffensen, PhD, Department of Microbiology and Molecular Biology Introduction Dopamine (DA) is a neurotransmitter in the brain that plays a role in several functions […]
Development of Chimeric Antigen Receptor T Cells to Target Cancer
Crandall, Justin Development of Chimeric Antigen Receptor T cells to Target Development of Cancer Faculty Mentor: Dr. Scott Weber, Department of Microbiology and Molecular Biology Introduction Cancer negatively affects the lives of millions of individuals, and remains a difficult ailment to treat. In 2014, approximately 585,720 deaths and 1,665,540 new cases of cancer were reported […]
Discovery of the Oxytocin Receptor Gene in Titi Monkeys
Page, Esther Discovery of the Oxytocin Receptor Gene in Titi Monkeys Faculty Mentor: James Dee Higley, Psychology Titi monkeys, are a new world monogamous nonhuman primate that bonds for life. Their monogamous nature makes them an ideal model for studying parenting behavior as well as social partner relationships (i.e., husband and wife). Non-human primates are […]
Novel G-protein Coupled Receptor Expression and Modulation of Synaptic Plasticity
Michael Thayer Christensen and Dr. Jeff Edwards, Physiology and Developmental Biology Introduction According to the Centers for Disease Control and Prevention, Alzheimer’s disease – infamously known for its patients’ loss of memory and other intellectual abilities – is the sixth most common cause of death in the United States. Sadly this is just one of […]
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