Joshua Wilkerson and Dr. Thomas Knotts, Chemical Engineering Introduction Proteins are versatile biological molecules that catalyze chemical reactions, provide cellular structure, and transport materials throughout the body. Proteins have been adapted for use in a wide variety of industries including food processing, medical diagnostics, and therapeutics. However, proteins must often be modified to enhance their […]
Search Results for: protein
The Effect of Deep Tissue Heating On Skeletal Muscle PGC1 a Protein Expression During Muscle Atrophy
Kaitlin Abbott, Dr. Allen Parcell, Exercise Sciences Introduction Through this project, we aimed to determine if repeated heat stress is a viable treatment to reduce or slow muscle atrophy in human muscle subjected to disuse. Specifically, I investigated how repeated heat stress affects the expression of PGC1-a, a gene that is an upstream regulator of mitochondrial […]
Determination of Binding of Capillary Morphogenesis Gene Protein 2 (CMG2) to Several Extracellular Matrix Proteins Under Physiological Conditions
Samuel Garrard and Dr. Kenneth Christensen, Department of Chemistry and Biochemistry Introduction: Pathological angiogenesis, or new blood vessel formation, is required for the progression of many diseases, including cancer, macular degeneration, and many other pathologies. Effective inhibition of angiogenesis would greatly augment current treatments for both cancer and eye disease. Previous research has implicated CMG2 […]
PbSe and PbTe Quantum Dots inside the Ferritin Protein
Kameron Hansen and Dr. John Colton, Department of Physics and Astronomy Ferritin (FTN) is a spherical protein shell used nearly ubiquitously across life to store and transport iron in a non-toxic form. Ferritin’s natural occurring ferrihydrite mineral (Fe(O)OH) can be removed, leaving behind a hollow interior that conveniently serves as a template for researchers to […]
The Effect of Repeated Heat Stress on Mitochondrial Protein Content in Human Skeletal Muscle
Amy Twitchell and Faculty Mentor: Robert Hyldahl, Exercise Science Introduction: Exercise has been known to improve mitochondrial function and increase its content in muscle. However, those who suffer from certain diseases such as Chronic Obstructive Pulmonary Disease (COPD) and Type II Diabetes often experience concomitant exercise intolerance. In vitro research suggests that the application of […]
The Effect of Repeated Heat Stress on Mitochondrial Protein Content in Human Skeletal Muscle
Amy Twitchell and Faculty Mentor: Robert Hyldahl, Exercise Science Introduction: Exercise has been known to improve mitochondrial function and increase its content in muscle. However, those who suffer from certain diseases such as Chronic Obstructive Pulmonary Disease (COPD) and Type II Diabetes often experience concomitant exercise intolerance. In vitro research suggests that the application of […]
Function of Ric-8A in G protein e+- Subunit Biogenesis
PI: Barry Willardson Students Involved Grant Ludlam. The MEG award helped support Grant’s work from January 2015 through August 2016. During this time Grant has worked on three projects. He investigated the role of Ric8A in the folding of the G protein a subunit and its assembly into the G protein heterotrimeric complex. Unfortunately, his […]
Effects of muscle cooling on AMPK and protein synthesis in skeletal muscle
Lyons, Kyle EFFECTS OF MUSCLE COOLING ON AMPK AND PROTEIN SYNTHESIS IN SKELETAL MUSCLE Faculty Mentor: David Thomson, PDBIO Background AMP-activated protein kinase (AMPK) is an intracellular protein that regulates many signaling responses including the mechanistic target of rapamycin (mTOR) pathway, which increases protein synthesis1. Recent research suggests that cold-water immersion of the leg activates […]
Using a TNP fluorophore to identify adenosine binding in the SNAP25B SNARE binding protein
David Hallan and Dixon Woodbury, Department of Physiology & Developmental Biology Introduction Vesicle fusion is a key step in the cellular process of exocytosis and is at the center of neurotransmitter release by neurons. Fusion is driven by a set of proteins known as SNAREs which includes the protein SNAP25B. In the synthesis and spectroscopic […]
Integration Host Factor Stabilized PCR- amplified DNA for High-Throughput Protein Synthesis Subtitle
William Bradley Faculty Mentor: Bradley Bundy, Dept. of Chemical Engineering Introduction As the search continues for novel proteins with market-incentivized properties, the demand for tools to accelerate the identification of these proteins increases. This has led to investigating methods for screening proteins that yield faster results (high-throughput) with greater titers of protein stable enough for […]
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