Collin Sanderson and Jonathan Alder, Physiology and Developmental Biology Department Introduction Telomeres are repetitive DNA sequences found on the ends of chromosomes that serve to protect the genes contained within each chromosome. As a cell replicates, its telomeres shorten, eventually triggering cellular senescence or death. This serves as a tumor suppressive mechanism by limiting the […]
Search Results for: mechanism
Alzheimer’s Disease: A New Model Defining the Mechanism of Iron- Catalyzed Radical Damage to Neurons
PI: Richard Watt Co-PI: Jonathan Wisco The MEG proposal focused on understanding how elevated homocysteine levels cause the inability of cells to control iron levels as a cause for Alzheimer’s disease. Iron is associated with the amyloid plaques and tau tangles that are proposed to cause damage to neurons. Dr. Wisco and I previously submitted […]
The Role of peripheral mechanisms on DA enhancement in the rodent brain
Christian Carr and Scott Steffensen, Department of Psychology Introduction Dopamine is an important brain neurotransmitter regarding brain disorders such as substance abuse, Schizophrenia, Parkinson’s disease, attention deficit hyperactivity disorder (ADHD), and Restless Leg Syndrome (RLS). Dopamine neurons in the ventral tegmental area (VTA) and substantia nigra (SN) are inhibited by DA via DA D2 autoreceptor […]
Mnemonic Mechanisms for the Mundane: A Longitudinal Approach
Athena Howell and Brock Kirwan, Department of Neuroscience/Psychology Introduction My project focused on the neural activity associated with memory consolidation, particularly the role of pattern separation and pattern completion over an extended period of time. Pattern separation occurs when the brain successfully encodes similar experiences into distinct memories (Deng et al. 2003); for instance, pattern […]
Elucidation of Mechanisms Whereby Embryonic Chicken Limbs Develop
Broadbent, James Elucidation of Mechanisms Whereby Embryonic Chicken Limbs Develop Faculty Mentor: Jeffrey Barrow, Department of Physiology and Developmental Biology Introduction As established by John Saunders 60 years ago, the AER is required for limb growth and patterning. However, the mechanisms whereby the AER regulates these processes remain poorly understood. My professor and I propose […]
Cellular Mechanism of Thymidine Kinase 1 Secretion
Wei Meng and Kim O’Neill, Department of Microbiology and Molecular Biology Introduction Cancer remains the second most common cause of death in the US, accounting for nearly 1 of every 4 deaths. Studies have shown that the early detection of cancer leads to better patient prognosis and a greater five-year survival rate. [1] Diagnostic and […]
Determining the Mechanism of Cocoa-Derived Epicatechin Enhancement of Glucose Stimulated Insulin Secretion
Benjamin Bitner, and Jeffery Tessem; Department of Nutrition, Dietetics, Food Science Introduction Due to recent increases in incidence, diabetes is now classified as a global epidemic. Diabetes results from the eventual destruction of β-cell mass, which causes decreased insulin secretion. Increasing functional β-cell mass may provide a cure for diabetes. A previous study has shown […]
Analysis of the kinetics and recombinatorial mechanisms of HIV-1 evolution in vivo in humanized mice
Bradford Berges, MEG 2013 Final Report (submitted Oct 2015) Evaluation of how well the academic objectives of the proposal were met Several of my students have moved on to future positions, as follows: Medical school: Sterling Adams, German Cuadra, Art Lee (still interviewing), and Tyler White (still interviewing) Graduate school: Steve Hallam See below in […]
Design of a 2-D Haptic Interface with Compliant Mechanism Actuation
Austin Rogers and Mark Colton, Mechanical Engineering Introduction The purpose of this research project was to improve the fidelity of haptic interfaces through the use of compliant mechanisms. “Haptics is the science and technology of experiencing and creating touch sensations in human operators” [1]. Traditional haptic interfaces include rigid links connected by rotary joints. The […]
A Load Shaping Demand Response Mechanism for Energy Consumers in a Smart Grid
Gerrit Noorda, Braden Hancock and Christopher A. Mattson, Mechanical Engineering Department Introduction In our proposal for an ORCA grant, we planned to use machine learning to socially benefit others with our research. In the early stages of the research, however, we came across a different, more urgent problem. We decided to use the same principles of […]
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