John Kauwe, Biology Project Justification and Overview Successful enrollment in and completion of graduate programs requires a constellation of skills. Students must be prepared to plan and execute experiments, present their findings both verbally and in manuscript form and interact effectively with senior scientists in the field of their choice. In this MEG I will […]
Search Results for: gene
Development of Real-Time Polymerase Chain Reaction (q-PCR) Assays for the Detection and Identification of Drug-resistance Genes in Carbapenem-resistant Enterobacteriaceae (CRE)
Richard A. Robison, Ph.D., Microbiology and Molecular Biology I. The Specific aims for the project were as follows: Develop q-PCR assays for the various carbapenem-resistance genes, such as KPC, IMP, VIM, and NDM-1, and then multiplex them into single assays that can be used to quickly characterize an isolate. II. Accomplishments to date related to […]
The Economics Behind the Construction of the General Relief Society Building
Kiersten Robertson and Mary Jane Woodger, Church History and Doctrine Introduction A building designated specifically for the use of the women of the Church of Jesus Christ of Latter-day Saints was first proposed in 1893, shortly after the dedication of the Salt Lake Temple. In response, the First Presidency offered a lot just east of […]
Oxytocin and Social Affiliation: A Study of the Genetic Underpinnings behind Social Behavior in Rhesus Macaques
Ryno Kruger, J. Dee Higley, Psychology Introduction Studies suggest that social relationships play a critical role in physical and mental health1, with effect sizes similar to that seen for smoking and alcohol abuse. Those experiencing real or perceived social isolation show higher rates of mortality3, while those with stronger social relationships show decreased rates of mortality4. […]
Transforming health through Precision Medicine: Content analysis of U.S. guidelines related to genetic counseling and testing
Nicole Jackson, Deborah Himes, BYU College of Nursing My mentor and I conducted a descriptive, mixed-methods study involved content analysis of U.S. Guidelines as they relate to Precision Medicine. We were able to identify the prevalence of Precision Medicine healthcare guidelines through the completion of this project. In working with my mentor, I was able to […]
Cancerous Male and Female Gene Expression
Clarissa Farmer and E. Shannon Tass, Statistics Genetic diagnosing is becoming more popular, as well as more and more accurate. However, many genetic diseases have complex genetic effects and are still not fully understood. Transthyretin Amyloidosis (ATTR; also known as familial or hereditary amyloidosis) is a terminal genetic disease. It is caused by unstable transthyretin […]
Genetic Susceptibility to Co-infections Involving Respiratory Syncytial Virus (RSV): Impact on Immunocompromised Adults
Taylor Brown, Dr. Chantel Sloan, Department of Health Science Respiratory Syncytial Virus (RSV) infects almost all infants before their second birthday and can progress to lower respiratory infections such as bronchiolitis or pneumonia. However, few are aware of the effect this has on adults, particularly those who are immunocompromised through organ or bone marrow transplants, treatments […]
An Efficient Method for Generating Conditional Cell Lines for Cellular and Molecular Research
Mark Roth and Dr. Jonathan Alder, Department of Physiology and Developmental Biology Conditional cell lines are widely used throughout biochemical research. The basic concept is that you can delete a gene you are studying upon the addition of a drug, to cells in culture, and then use the knockout cells to study the genes effects. […]
Determination of Binding of Capillary Morphogenesis Gene Protein 2 (CMG2) to Several Extracellular Matrix Proteins Under Physiological Conditions
Samuel Garrard and Dr. Kenneth Christensen, Department of Chemistry and Biochemistry Introduction: Pathological angiogenesis, or new blood vessel formation, is required for the progression of many diseases, including cancer, macular degeneration, and many other pathologies. Effective inhibition of angiogenesis would greatly augment current treatments for both cancer and eye disease. Previous research has implicated CMG2 […]
Engineering a Cancer Specific 3rd Generation CAR Immunotherapy
Josie Tueller and Faculty Mentor: K. Scott Weber, Department of Microbiology and Molecular Biology This project aimed to develop a cancer-specific immunotherapy that will target and destroy cancer cells without killing healthy cells. Current cancer treatments struggle to successfully target cancer cells and commonly target all rapidly dividing cells (both healthy and cancerous). Chimeric antigen […]
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