Andrew Barlow, Trevor Lloyd, Mason Poffenbarger, Austin Ricks, Dr. Jeffery Tessem; Nutrition, Dietetics, and Food Science Introduction Diabetes’ prevalence is increasing at an alarming rate. Normally, insulin-secreting β-cells in the pancreas regulate proper glucose absorption and storage. Type 1 and Type 2 diabetes are characterized by decreased functional β-cell mass and insulin production (1). Diabetes also results […]
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Iron Dysregulation induced by Oxidative Stress is Prevented by Curcumin in C2C12 Skeletal Muscle Cells
Jacob Anderson, Dr. Chad Hancock; Nutrition, Dietetics, and Food Science Introduction Recent studies indicate a correlation between iron dysregulation and insulin sensitivity, suggesting that iron dysregulation may play a role in the development of type 2 diabetes mellitus [1]. However, the connection between iron regulation and insulin sensitivity is not fully understood. Iron is normally tightly regulated, and […]
Glutathione-Mediated Oxidative Response in UVB-Irradiated HaCaT Cells
Patrick Badger and Dr. Jason Hansen, Department of Physiology and Developmental Biology Introduction Ultraviolet light (UV) plays a critical role in the etiology of skin cancer, contributing to over 95% of both melanoma and non-melanoma diagnoses. It consists of several wavelengths, among which UVB is the most harmful, causing inflammation associated with sunburn and constituting […]
Differentiation of Kidney progenitors using Induced Pluripotent Stem Cells and Conditioned Media of Renal Cortical Tubular Epithelial Cells
Steven Passey and Dr. Alonzo Cook, Chemical Engineering Department Introduction: According to the National Kidney Foundation, 26 million American adults have kidney disease, 47,000 Americans died from kidney disease in 2013, and over 100,000 people await kidney transplants. Current treatment of kidney failure includes dialysis and kidney transplant. Unfortunately, those undergoing dialysis may experience fatigue […]
The Effect of the Overexpression of IRF% in B-Cells on Inflammatory and Co-Stimulatory Activity
Reika Takita and Faculty Mentor: Brian Poole, Microbiology and Molecular Biology
Induction of Differentiation of Human Induced Pluripotent Stem Cells into Glucose Responsive Beta Cells
Caden Duffy and Faculty Mentor: Alonzo Cook, Chemical Engineering Introduction: Type 1 Diabetes (T1D) is an autoimmune disease that affects 1.25 million people in the United States, according to the American Diabetes Association. Although there are many short-term methods for regulating blood sugar levels, the only permanent cure for T1D currently is a pancreatic or […]
Development of Chimeric Antigen Receptor T Cells to Target Cancer
Crandall, Justin Development of Chimeric Antigen Receptor T cells to Target Development of Cancer Faculty Mentor: Dr. Scott Weber, Department of Microbiology and Molecular Biology Introduction Cancer negatively affects the lives of millions of individuals, and remains a difficult ailment to treat. In 2014, approximately 585,720 deaths and 1,665,540 new cases of cancer were reported […]
Identifying the Upstream Target of Resveratrol in Breast Cancer Cells
Jeffrey Mecham and Jason Kenealey; Department of Nutrition, Dietetics, & Food Science Introduction One commonly disrupted pathway in many different cancer cells lines revolves around the tumor suppressor protein p53. Approximately half of human cancers exhibit direct, inactivating mutations of p53, while the majority of the remainder either elevate inhibitors, reduce activators, or deactivate downstream targets […]
Fabrication of Dye Sensitized Solar Cells Using Native and Non-Native Nanocrystals in Ferritin as the Dye
Alessandro Perego and John Colton, Physics and Astronomy Introduction Dye-sensitized solar cells (DSSCs) present a valuable and sustainable alternative to silicon solar cells. These cells present numerous advantages compered to inorganic photovoltaic systems, such as ability of absorb more sunlight per surface area than standard silicon-based solar panels, DSSCs are also able to work even […]
Final Report for 2013 MEG: Improving the memory response of pathogen specific helper T cells
Scott Weber – Department of Microbiology and Molecular Biology The following two aims are from my 2013 MEG. We made great progress and completed most of both Aim 1 and Aim 2. Details on the progress for each aim are described below. Mentoring Environment: This MEG allowed me to expand the size of my lab […]
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