Scott Weber, Microbiology and Molecular Biology 1) Project Summary This project was focused on improving the immune response to infectious disease and cancer. We have engineered T cell receptors with 1000-fold increase in affinity and will characterize their value as diagnostics and therapeutics. In addition, we examined changes in T cell function due to the […]
Search Results for: cancer
Quantifying predictive value of biological data types in machine learning models of cancer outcome
Samantha Jensen, Stephen Piccolo, Biology Precision medicine is a growing movement toward utilizing molecular diagnostics to guide medical decisions. It is particularly useful when applied to cancer treatment, as knowing details about cancer stage, genetic pathology, and tumor type can inform life-saving decisions. Increasingly, physicians may use genetic, proteomic, epigenetic, and expression data to determine treatment […]
Cancerous Male and Female Gene Expression
Clarissa Farmer and E. Shannon Tass, Statistics Genetic diagnosing is becoming more popular, as well as more and more accurate. However, many genetic diseases have complex genetic effects and are still not fully understood. Transthyretin Amyloidosis (ATTR; also known as familial or hereditary amyloidosis) is a terminal genetic disease. It is caused by unstable transthyretin […]
Engineering a Cancer Specific 3rd Generation CAR Immunotherapy
Josie Tueller and Faculty Mentor: K. Scott Weber, Department of Microbiology and Molecular Biology This project aimed to develop a cancer-specific immunotherapy that will target and destroy cancer cells without killing healthy cells. Current cancer treatments struggle to successfully target cancer cells and commonly target all rapidly dividing cells (both healthy and cancerous). Chimeric antigen […]
A metagenome-wide association study of gut microbiota in Drosophila cancer metastasis.
Anthony Caruso and Faculty Mentor: John Chaston, Plant and Wildlife Sciences Introduction It has been established by past scientific research that the gastrointestinal microbiome plays a defined role in many human diseases. Some of these diseases include inflammatory bowel disease, autism, hypertension, and even cancer. A common symptom seen in many of these diseases is […]
TRF1 Mutations as a Mechanism for Telomere Length Maintenance in Cancer
Collin Sanderson and Jonathan Alder, Physiology and Developmental Biology Department Introduction Telomeres are repetitive DNA sequences found on the ends of chromosomes that serve to protect the genes contained within each chromosome. As a cell replicates, its telomeres shorten, eventually triggering cellular senescence or death. This serves as a tumor suppressive mechanism by limiting the […]
Development of Chimeric Antigen Receptor T Cells to Target Cancer
Crandall, Justin Development of Chimeric Antigen Receptor T cells to Target Development of Cancer Faculty Mentor: Dr. Scott Weber, Department of Microbiology and Molecular Biology Introduction Cancer negatively affects the lives of millions of individuals, and remains a difficult ailment to treat. In 2014, approximately 585,720 deaths and 1,665,540 new cases of cancer were reported […]
Thymidine kinase 1: the key to predicting cancer recurrence
Brog, Rachel Thymidine kinase 1: the key to predicting cancer recurrence Dr. Kim L. O’Neill, Microbiology and Molecular Biology Introduction Currently it is estimated that over 230,000 women will be diagnosed with breast cancer this year in the United States alone. Although treatments are improving, an alarming number of these cases will show cancer recurrence […]
Transition From Cardiovascular Disease to Cancer as the Leading Cause of Death in US States, 1999-2014
Michael C. Harding and Evan Thacker, Department of Health Sciences INTRODUCTION: In 1900 the three leading causes of death in the United States were pneumonia and influenza; tuberculosis; and gastritis, enteritis, and colitis.1 However, through a combination of improved sanitation, the discovery of antibiotics, and the advent of vaccination programs, deaths from infectious diseases subsided […]
Examining Gene-Expression Patterns Across Rare Colon Cancer Syndromes to Identify Early Diagnosis and Treatment Options
Hawkes, Douglas Examining Gene-Expression Patterns Across Rare Colon Cancer Syndromes to Identify Early Diagnosis and Treatment Options Faculty Mentor: Stephen Piccolo, Biology Introduction Colon cancer often runs in families. Individuals in these families have a relatively high lifetime risk of developing colon cancer and often develop aggressive tumors at a relatively young age. Currently, genetic […]
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