I received funding for this MEG in January of 2015. This was a remarkably fruitful MEG for my lab. The work completed through this grant proposal led to some ground breaking data that translated into two patent applications (Topical/Transdermal application of wogonin for promoting chondrocyte autophagy, leading to reversal of damage associated with osteoarthritis as well as blocking joint pain; Topical/surface application of TAK-242 as a treatment for pain associated with osteoarthritis), two papers (Brand J. Rose, Robert E. Seegmiller, Laura C. Bridgewater, David L. Kooyman. Collagen Mutant Mouse Models Provide an Important Tool to Study Osteoarthritis. 2016. Journal of Arthritis 5:5 3 pages; CS Black, PK Crepeau, ID Sheffield, JR Macdonald, DJ Wootton, Baek M, DL Eggett, PR Reynolds and DL Kooyman. Identification of the Tidemark Line of Calcification in Osteoarthritic Cartilage Using A Stain for Alkaline Phosphatase. 2017. Journal of Arthritis 6:1 5 pages) and one abstract at an international meeting (C.S. Black, P.K. Crepeau, I.D. Sheffield, J.R. Macdonald, D.J. Wootton, M. Baek, D.L. Eggett, P.R. Reynolds, D.L. Kooyman. Identification of the Tidemark Line of Calcification in Osteoarthritic Cartilage Using a Stain for Alkaline Phosphatase. 2015. Osteo and Cart. 23: 198). A number of undergraduate (6 became co-authors) and one graduate student (also a co-author)participated in this important work. It also resulted in enough data that we were able to submit a grant application to the Department of Defense. The grant is currently under review and we should know by December 2017 if it was funde the lives of students while conducting cutting-edge research.d. Thank you for this opportunity to help bless