Bioreactor Design for Viable Recellularization of Whole Porcine Kidney

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Wandelt, Kennedy Bioreactor Design for Viable Recellularization of Whole Porcine Kidney Faculty Mentor: Dr. Alonzo Cook, Chemical Engineering Kidney failure affects tens of thousands of individuals annually causing many to rely on dialysis to replace this organ’s function. Most of these individuals are on a waiting list to receive a transplant for years, and unfortunately […]

Cell Attachment to Alginate Hydrogel Structures

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Livingston, Sarah Cell Attachment to Alginate Hydrogel Structures Faculty Mentor: Dr. Alonzo Cook, Chemical Engineering Introduction One of the most pressing needs within the medical community is the demand for transplantable organs. On average, 22 people per day on average die waiting for a transplant. Even if a patient receives an organ, the risks associated […]

Re-epithelialization of whole porcine kidney scaffold

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Re-epithelialization of whole porcine kidney scaffold Evan M. Buckmiller, Advisor: Alonzo D. Cook, Department of Chemical Engineering Introduction An estimated 20 million adults (approximately 10% of all individuals over the age of 18) in the United States suffer from some level of chronic kidney disease (CKD), making CKD the 9th leading cause of death in […]

A Solution to the Problems of Heart Transpantation

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Struk, Jeremy Men’s Hearts Shall Fail Them: A Solution to the Problems of Heart Transplantation Faculty Mentor: Alonzo Cook, Chemical Engineering Ischemic Heart disease, according to the World Health Organization, is the leading cause of death in the USA and abroad.1 As a result of the high incidence of the disease and low transplant availability, […]

Thermally Stable Support for Improved Synthetic Fuel Catalysts

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Mark Lindsay, Dr. William Hecker and Dr. Morris Argyle, Department of Chemical Engineering Introduction Fischer-Tropsch Synthesis (FTS) has attracted interest recently as large natural gas deposits have been discovered across the globe. FTS is a gas-to-liquid technology that produces fuels with far fewer sulfur or nitrogen impurities, making it an attractive cleaner alternative to petroleum […]

Pluripotent Stem Cell (iPSC) Differentiation to Kidney Phenotype with Conditioned Media of RCTEs

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Angela Nakalembe and Dr. Alonzo Cook, Department of Chemical Engineering Introduction According to the latest U.S. Renal Data System Annual Data Report, more than 660,000 Americans are currently being treated for kidney failure, also called end stage renal disease (ESRD). The current treatment options, dialysis and kidney transplants, work well in some instances but have […]

Insulin, Glucose, and β-cell Diffusion Analysis

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Matthew Usevitch and Alonzo Cook, Department of Chemical Engineering Introduction: The purpose of this project is to further understand the function of extruded polytetrafluoroethylene (ePTFE) membranes in the pursuit of creating an implantable, removable pancreas device. This device would be filled with pancreas cells and automatically regulate blood sugar for patients with diabetes. Dr. Alonzo […]

Differentiation of iPSCs into Cardiomyocytes Utilizing Extracellular Matrix

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Arthur Castleton and Alonzo Cook, Department of Chemical Engineering Introduction According to the American Heart Association, Ischemic heart disease is the principal cause of death. Many potential therapies are being simultaneously explored and among the most promising is tissue engineering of cardiac scaffolds. In vitro culturing of mature cardiomyocytes has the potential to lay the […]

Biosensor System for the Detection of Endocrine Disrupting Chemicals

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Conner Earl and Bradley Bundy, Department of Chemical Engineering Department *Note: this report contains proprietary information and should not be circulated publicly until the final research report is accepted and published in a scientific journal. (one year) Introduction Endocrine Disrupting Chemicals (EDCs) present problems worldwide and have been linked to cancer, developmental disorders, and other […]