Jeffrey Clark and Dr. Paul B. Savage, Chemistry and Biochemistry Introduction One current problem in medicine is the accumulation of biofilm on medical devices. Bacterial colonization of endotracheal tubes and urinary catheters is the leading cause of hospital-acquired infections. These infections contribute significantly to patient mortality rates and care costs1. Ceragenin-containing thin films have the […]
Membrane Depolarization Due to Cationic Steroid Antibiotics
Jonathan O. Wright and Dr. Paul Savage, Department of Chemistry and Biochemistry The project that I have worked on this past year has been focused on a novel group of antibiotics developed in the lab of Dr. Savage. The antibiotics, called ceragenins or cationic steroid antibiotics (CSA’s), are molecules synthesized from cholic acid, a common […]
ION BEAM MAPPING INSIDE AN INDUCTIVELY COUPLED PLASMA MASS SPECTROMETER USING LASER INDUCED FLUORESCENCE
Brett S. Duersch and Dr. Paul B. Farnsworth, Chemistry and Biochemistry Inductively coupled plasma mass spectrometry (ICP-MS) is one of the fastest growing fields in analytical chemistry. This discipline combines the powerful detection of mass spectrometry (MS) with the almost universal ionization capabilities of the inductively coupled plasma (ICP) . Combing these two techniques is […]
COMPOSITE TEFLON AND POLYMER INCLUSION MEMBRANES FOR USE IN ION CHROMATOGRAPHY SUPPRESSORS
Tyler L. Crawford and Dr. John D. Lamb, Chemistry and Biochemistry Ion chromatography (IC) has a need for a suppressor which would allow the simultaneous conductitnetric detection of both cations and anions. Such a suppressor’s membrane would need to exhibit a large flux and a high level of selectivity. Polymer inclusion membranes (PIMS) containing macrocycles […]
Synthesis of MDR-Homodimers Used to Explore the Structure of P-Glycoprotein
Emily Parker Updegraff and Dr. Merritt B. Andrus, Chemistry and Biochemistry Chemotherapy is one of the primary methods of combating cancer, and if it fails, the patient may be left with few options for treatment. Multi-drug resistance (MDR) is a clinical condition manifested by the failure of chemotherapy. It is primarily due to the expression […]
FRACTIONATION AND ISOLATION OF THE ANTI-TUMORAL ACTIVITY OF AN INDIGENOUS TONGAN MEDICINAL EXTRACT
Steven D. Christenson and Drs. Gary M. Booth and Steven G. Wood Vai Haka is the Tongan name given to a medicinal extract prepared and prescribed by indigenous healers on the island kingdom of Tonga. Used as a treatment for morning sickness (hyper-emesis), the mixture is prepared by boiling the barks of four different rainforest […]
PIXE ANALYSIS OF HUMAN HAIR FROM AN EGYPTIAN CEMETERY
Rafael Casellas and Drs. Nolan F. Mangelson and Lawrence B. Rees, Chemistry and Biochemistry Human hair is considered to be a minor excretory organ for trace elements. The literature suggests that in some cases trace elemental concentration varies in different races of people. In addition, hair analysis has been used to assess nutritional status in […]
RESEARCHING MOLECULAR MECHANICS
Kent Bower, Chemistry The use of Molecular Mechanics has taken a strong foothold in the world of computational chemistry today. Molecular Mechanics methods offer quick solutions to complex molecular conformation calculations that could take up to days or even months to perform on supercomputers using more exact methods, such as ab initio calculations. For this […]
Synthesis of Lipid A Analogues and the Study of Their Interactions with Antibiotics
Glade E. Roper and Dr. Paul B. Savage, Chemistry and Biochemistry Septic shock is a disease that kills over 100,000 hospitalized patients in the United States every year. The mortality rate for those who fall into septic shock is between fifty and eighty percent, and despite advances in medicine this rate has remained constant over […]
DEVELOPMENT OF NEW LIPID A-BINDING AGENTS
Mark Benson and Dr. Paul B. Savage, Chemistry and Biochemistry The aim of this project is to synthesize a non-peptide lipid A-binding agent which is less toxic and simpler than polymyxin B. Such a binding agent could be used to fight sepsis, a toxic condition where the body overreacts to the lipid A portion of […]
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