Timothy McClain and Professor David Busath, Department of Physiology and Developmental Biology Goal/Purpose of the Project The purpose of this project was to research and test various drug compounds to prevent influenza virus infection. A specific target of my research is M2 protein channels that aid in the uncoating of the viral coat. Recent mutations have rendered formerly […]
Characterizing Proteins that Interact with PAS Kinase
Jordan Mackay and Dr. Julianne Grose, Department of Microbiology and Molecular Biology Characterizing the interacting protein partners of Per-Arnt-Sim (PAS) kinase has proven to be a formidable task. Since the beginning of 2012, I have been working hard with graduate student Desi DeMille on confirming the putative interactors uncovered by genetic screening done the previous […]
The Spondyloepiphyseal Dysplasia Congenita homozygous Mutant: A Model for the Mechanism of Osteoarthritis
David Macdonald and Dr. Robert Seegmiller, Department of Physiology and Developmental Biology Articular cartilage is a hard-wearing and specialized form of hyaline cartilage which allows for an almost frictionless surface during joint movement (Ofek et al. 2008). These unique characteristics are primarily due to chondrocyte secretions, and the composition and properties of the extracellular matrix (ECM) (Buckwalter and […]
EBI2 Knockdown and Effects on B-Cell Migration
Jordan Mabey and Dr. Brian Poole, Department of Microbiology and Molecular Biology Introduction B cells are specialized cells which participate in the normal immune response to an infection. As B cells encounter antigens in the body, they become activated and travel to what is known as a B cell follicle within a lymph node. At […]
Interaction – Characterizing the Effect of Chromosome 21 on Both Tau and Aß42 in Alzheimer’s Disease
Mo Lee and Dr. John Kauwe, Department of Biology It turns out that the data for chromosome 21 didn’t come to me at all. There were some problem with the data itself according to our co-researchers. However, the data for the phenotype YKL40, which is a promising gene that might affect the pathology of Alzheimer’s Disease. Dr. […]
Phylogeny of Acridoidea (Orthoptera: Caelifera) based on Complete Mitochondrial Genome Data: Testing Partition Strategies
James Leavitt and Dr. Michael Whiting, Department of Biology Goal/Purpose of the Project The orthopteran superfamily Acridoidea (Orthoptera, Caelifera), which includes grasshoppers and their nearest relatives, is the largest of the orthopteran superfamilies and provides an excellent model for studying the evolution of mitochondrial genomes. Ultimately I was able to reconstruct a phylogeny for Caelifera […]
Assessing the Effects of the IRF5 Exon 1B on Translation
Jared Lambert and Dr. Brian Poole, Department of Microbiology and Molecular Biology With our lab’s previous finding revealing a hairpin folding structure in exon 1B (IRF5 risk allele), not found in the other first exons, this project was focused towards more fully understanding the role of IRF5 exon 1B’s hairpin structure and its effect on […]
Detection of Genetic Variants Affecting MMP Protein Expression: A genome-wide association study approach
Krista Klingler and Dr. John Kauwe, Department of Biology Alzheimer’s disease is the most common form of dementia, affecting over 35 million people worldwide. However, the pathology of the disease is not fully understood. Because of this, no cure for the disease currently exists, and once a patient has been diagnosed with Alzheimer’s disease, death […]
Understanding the Molecular Targets of Antimicrobial Chemokines
Brittany Kartchner and Dr. Eric Wilson, Department of Microbiology and Molecular Biology For this project, I hypothesized that the amino acid composition of the C terminus of chemokine proteins allows some chemokines to bind to different sites on the bacterial cell wall and that the chemokines with a strong positive charge (CCL25 and CCL28) will […]
The Efffect of Precipitation Frequency and Magnitude on Engelmann Spruce
Sarah Karlinsey and Dr. Richard Gill, Department of Biology I was able to present my findings in poster-‐form at the Ecological Society of America conference in Portland, Oregon in August. Dr. Gill and I are now in the process of writing up a paper about our work to be submitted to Tree Physiology or the […]
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